PMID: 8962098Dec 10, 1996Paper

Phospholipase C beta 4 is involved in modulating the visual response in mice

Proceedings of the National Academy of Sciences of the United States of America
H JiangD Wu

Abstract

Expression of G protein-regulated phospholipase C (PLC) beta 4 in the retina, lateral geniculate nucleus, and superior colliculus implies that PLC beta 4 may play a role in the mammalian visual process. A mouse line that lacks PLC beta 4 was generated and the physiological significance of PLC beta 4 in murine visual function was investigated. Behavioral tests using a shuttle box demonstrated that the mice lacking PLC beta 4 were impaired in their visual processing abilities, whereas they showed no deficit in their auditory abilities. In addition, the PLC beta 4-null mice showed 4-fold reduction in the maximal amplitude of the rod a- and b-wave components of their electroretinograms relative to their littermate controls. However, recording from single rod photoreceptors did not reveal any significant differences between the PLC beta 4-null and wild-type littermates, nor were there any apparent differences in retinas examined with light microscopy. While the behavioral and electroretinographic results indicate that PLC beta 4 plays a significant role in mammalian visual signal processing, isolated rod recording shows little or no apparent deficit, suggesting that the effect of PLC beta 4 deficiency on the rod signaling pathway oc...Continue Reading

References

May 7, 1990·Biochimica Et Biophysica Acta·L BirnbaumerA M Brown
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D WuM I Simon
Jan 1, 1993·Cell·S H DeVries, D A Baylor
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·L M Shulman, D A Fox

❮ Previous
Next ❯

Citations

Apr 18, 2008·The Cerebellum·Seung-Hyuk ChungRichard Hawkes
Jan 24, 2004·Brain Research. Brain Research Reviews·John W Phillis, Michael H O'Regan
Aug 6, 2002·Survey of Ophthalmology·Sascha FauserFrank Schüttauf
Jun 7, 2003·Advances in Enzyme Regulation·Kiyoko FukamiTadaomi Takenawa
Feb 5, 1999·Biochimica Et Biophysica Acta·F M AdamskiB H Shieh
Aug 1, 1997·Current Opinion in Neurobiology·K Palczewski, J C Saari
Dec 27, 2011·Nature Neuroscience·Sukchan LeeHee-Sup Shin
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·W XieD Wu
Apr 16, 2008·The Journal of Biological Chemistry·Tamara I A RoachWilliam E Seaman
Aug 6, 2002·Frontiers in Bioscience : a Journal and Virtual Library·David Krizaj, David R Copenhagen
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·M KanoD Wu
Jul 3, 2008·BMB Reports·Pann-Ghill SuhSung Ho Ryu
Mar 18, 2017·The Journal of General Physiology·Gabriel Peinado AllinaMarie E Burns
Oct 9, 2007·Brain Research·Travis C JenkinsElizabeth L Meyer-Bernstein
Mar 7, 1998·The Journal of Biological Chemistry·M J KimP G Suh
Jan 12, 2017·Stem Cell Reports·Michiko MandaiMasayo Takahashi
Mar 8, 2013·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yasukazu HozumiKaoru Goto
Jul 6, 2004·The Journal of Comparative Neurology·David KrizajDavid R Copenhagen
Nov 28, 2002·The Journal of Comparative Neurology·Liquan HuangThomas Euler
Sep 5, 2009·The Journal of Comparative Neurology·Ji-Young KimRichard Hawkes
Apr 17, 2007·The Journal of Comparative Neurology·Hassan MarzbanRichard Hawkes
Jul 30, 2011·The Journal of Comparative Neurology·Alejandro VilaDavid W Marshak
Dec 29, 2011·The Journal of Biological Chemistry·Yanning WuChunying Li
Aug 1, 2013·Physiological Reviews·Tamas Balla
Jul 25, 2013·Molecular Pharmacology·Angeline M Lyon, John J G Tesmer
May 14, 2019·BioMed Research International·Tengfang ZhangXiaoyong Xie
Jun 30, 2019·The Journal of Biological Chemistry·Sidney M GospeVadim Y Arshavsky
Oct 4, 2000·Physiological Reviews·M J Rebecchi, S N Pentyala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.