Phospholipase C may be involved in norepinephrine-induced cardiac hypertrophy

Biochemical and Biophysical Research Communications
Tushi SingalP S Tappia

Abstract

Cardiac hypertrophy is characterized by increased cardiomyocyte size, mRNA levels for atrial natriuretic factor (ANF), and protein synthesis. Although activation of the phosphoinositide-specific phospholipase C (PLC) leads to the generation of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate, the involvement of PLC in hypertrophic response remains to be fully understood. The present study was therefore undertaken to examine if the inhibition of PLC activity is associated with a decrease in ANF expression and protein synthesis in cardiomyocytes, due to norepinephrine (NE), a known hypertrophic agent. NE resulted in an increase in ANF gene expression and protein synthesis in adult rat cardiomyocytes, these effects of NE were attenuated by a PLC inhibitor, U73122. The NE-induced increase in ANF gene expression and protein synthesis was also inhibited by an alpha-adrenoceptor blocker, prazosin. Both U73122 and prazosin depressed the NE-induced increase in DAG production in cardiomyocytes. These results indicate that the alpha-adrenoceptor mediated PLC activation may be involved in the process of NE-induced cardiac hypertrophy.

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Citations

May 10, 2007·Canadian Journal of Physiology and Pharmacology·Paramjit S Tappia
Apr 16, 2010·Canadian Journal of Physiology and Pharmacology·Paramjit S TappiaDelfin Rodriguez-Leyva
Oct 15, 2008·Journal of Molecular and Cellular Cardiology·Mario PatrizioGiuseppe Marano
Jul 8, 2008·Journal of Molecular and Cellular Cardiology·Jens KockskämperMartin D Bootman
Dec 7, 2007·British Journal of Pharmacology·P-A PaquetteS Mukaddam-Daher
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Melissa R DentP S Tappia
Jun 23, 2009·Journal of Cellular and Molecular Medicine·Tushi SingalParamjit S Tappia
Dec 14, 2005·Toxicology and Applied Pharmacology·Carolin Zwadlo, Jürgen Borlak
May 23, 2006·Journal of Molecular and Cellular Cardiology·Tushi SingalParamjit S Tappia
Nov 6, 2018·Canadian Journal of Physiology and Pharmacology·Sukhinder K CheemaNaranjan S Dhalla
Feb 20, 2009·Molecular and Cellular Biochemistry·Tushi SingalParamjit S Tappia
Feb 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Rabban MangatParamjit S Tappia
Dec 10, 2009·Physiology·Yoshikazu Nakamura, Kiyoko Fukami
Apr 25, 2014·American Journal of Physiology. Cell Physiology·Mohammed Emehdi Atef, Madhu B Anand-Srivastava

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