PMID: 2494375Feb 1, 1989Paper

Phospholipases and acyltransferases in macrophages

Klinische Wochenschrift
I FleschE Ferber

Abstract

In contrast to many other cells, macrophages contain a phospholipase A2, which preferentially liberates arachidonic acid from the main phospholipids. In unstimulated macrophages this acylchain-specific phospholipase A2 is localized in the lipid-free cytosol and thus without function. After activation of protein kinase C with diacylglycerols, the cytosolic phospholipase A2 is translocated to cellular membranes. The same activator of protein kinase C causes an inhibition of the acyl-CoA: lysophosphatide acyltransferase. This enzyme regulates the availability of free arachidonic acid for eicosanoid synthesis by reacylation into phospholipids. Thus protein kinase C seems to regulate the level of free arachidonic acid by opposite effects on the two major enzymes, which are responsible for the control of free arachidonic acid.

References

Jul 18, 1986·Science·Y Nishizuka
Sep 14, 1986·Biochemical and Biophysical Research Communications·H J PfannkucheK Resch
Dec 16, 1987·Biochemical and Biophysical Research Communications·T Schonhardt, E Ferber
May 1, 1985·Zeitschrift Für Naturforschung. Section C: Biosciences·I FleschE Ferber
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F HirataR del Carmine
Apr 15, 1982·The Biochemical Journal·R F Irvine

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Citations

Sep 14, 1994·Journal of Immunological Methods·P Dieter
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·P RosenbergC C Yang
Oct 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·T V Gowda, J L Middlebrook
Dec 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·R M Kini, H J Evans
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·Andreimar M Soares, José R Giglio
Dec 14, 2011·Biochimica Et Biophysica Acta·Alma M AstudilloJesús Balsinde
Sep 1, 2009·Biochimica Et Biophysica Acta·Gema Pérez-ChacónJesús Balsinde
Dec 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gema Pérez-ChacónJesús Balsinde
Oct 1, 1991·Biological Chemistry Hoppe-Seyler·P Dieter, E Fitzke
Feb 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·A J HietarantaT J Nevalainen

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