Phospholipid and cholesterol alterations accompany structural disarray in myelin membrane of rats with hepatic encephalopathy induced by thioacetamide

Neurochemistry International
I SwapnaB Senthilkumaran

Abstract

Fulminant hepatic failure is often associated with a wide range of neurological symptoms which are collectively referred to as hepatic encephalopathy. Fulminant hepatic failure with associated hepatic encephalopathy has a poor prognosis with the currently available sure treatment being only liver transplantation. This is largely owing to the lack of understanding of critical factors involved in the etiology of the condition. Lipid changes have been implicated in cerebral derangements characteristic of hepatic encephalopathy. About 79% of the brain lipid is concentrated in the myelin fraction where they play an important role in ion balance and conduction of nerve impulses. Hence, in the present study we aimed to investigate changes in myelin lipid composition and structure. Myelin was isolated by sucrose density gradient centrifugation from cerebral cortex of male Wistar rats (250-300 g body weight) treated with 300 mg/kg body weight thioacetamide administered twice at 24h interval to induce hepatic encephalopathy. Significant decrease was observed in the cholesterol and phospholipids content of myelin from treated rats. Sphingomyelin, phosphatidylserine and phosphatidylethanolamine content also decreased significantly followin...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Feb 1, 1978·Archives internationales de physiologie et de biochimie·B Sadasivudu, C Radha Krishna Murthy
Sep 1, 1990·Neurochemical Research·J OsadaM Cascales
Nov 24, 1987·Brain Research·J Miklossy, H Van der Loos
Apr 1, 1987·Physiological Reviews·A J Cooper, F Plum
Jul 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Zieve
Jan 1, 1982·Annals of Neurology·G R DeLong, T H Glick
May 1, 1982·Gut·N M BassS Sherlock
Apr 1, 1981·Intensive Care Medicine·S BraudeR Williams
Jan 4, 1993·Neuroscience Letters·S M DelaneyJ D Geiger
Feb 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C D GoveR Williams
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R BruckZ Halpern
Oct 14, 1998·The Journal of Physiology·J E SiroisD A Bayliss
Nov 17, 1999·Proceedings of the Society for Experimental Biology and Medicine·A S Hazell, R F Butterworth
Nov 6, 2001·Progress in Lipid Research·Henna Ohvo-RekiläJ Peter Slotte
Jul 30, 2003·Brain Research·Elena KosenkoVicente Felipo
Aug 14, 2003·Annals of Human Genetics·P E JiraR A Wevers
Feb 7, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Ingemar Björkhem, Steve Meaney
Jun 18, 2004·Journal of Alzheimer's Disease : JAD·Andrei C MiuMircea Miclea
May 14, 2005·Current Opinion in Neurology·Bernd C KieseierHans-Peter Hartung
Jun 13, 2006·Behavioural Brain Research·Andrei C MiuMircea Miclea
Aug 30, 2008·Emotion·Scott H HemenoverChristopher P Barlett
Jul 26, 2011·Current Opinion in Gastroenterology·Bobby J CherayilNandakumar N Shanmugam

❮ Previous
Next ❯

Citations

Nov 15, 2011·Neurotoxicology·Alessandra GilardiniDaniel A Kirschner
Aug 29, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Shi JinXiao-Dong Liu
Feb 9, 2017·Canadian Journal of Physiology and Pharmacology·Rasha E MostafaHanan A Ogaly

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.