PMID: 8612435Sep 1, 1995Paper

Phospholipid and glutamic acid decarboxylase autoantibodies in diabetic neuropathy

Diabetes Care
A I VinikS Suwanwalaikorn

Abstract

To determine the prevalence and significance of phospholipid autoantibodies (PLAs) and glutamic acid decarboxylase (GAD) autoantibodies in the circulation of normal patients and diabetic patients with and without neuropathy. We measured PLAs in a total of 78 patients (a diabetic group with somatic or autonomic neuropathy [n = 40] another group without neuropathy [n = 38]), and GAD autoantibodies in a subset of 22 patients. PLAs are found in 2% of the general population. We found PLAs in 32% of the diabetic population without neuropathy, in 88% of those with neuropathy, in 55% of those with retinopathy, and in 25% of those with established nephropathy. The frequencies of immunoglobulins in the neuropathic group were: IgG = 78%, IgM = 33%, and IgA = 23%. There was no correlation between PLAs and microalbuminuria, macrovascular disease, fibrinogen, duration of diabetes, or neuropathy, but there was a strong correlation with total neuropathy score. Sera with high PLA IgG titers bound to the surface of neuroblastoma cells and inhibited cell growth. Antibodies to GAD65 were present in 32% and to GAD67 in 0% of patients. No titers of GAD65, GAD67, or the GAD65 ratio were associated with the degree of neuropathy of the presence of PLAs...Continue Reading

Citations

Sep 14, 1999·The American Journal of Medicine·A I Vinik
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Jan 1, 1997·Pharmacology & Therapeutics·B V MacFarlaneH A Benson
Oct 30, 1999·Clinical and Experimental Immunology·P GargiuloJ A McIntyre
Jun 3, 2006·Diabetes/metabolism Research and Reviews·Johanna Rinta-ValkamaHarry Holthöfer
Dec 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·P MyhillT M E Davis
Jun 7, 2005·Diabetes Research and Clinical Practice·Ilhan TarkunZeynep Cantürk
Apr 19, 2005·Neuromuscular Disorders : NMD·Ricardo C ReisinMauricio Jadzinsky
Jul 27, 2005·Diabetes Care·Aaron I VinikJagdeesh Ullal
Mar 3, 2007·Journal of Neuroimmunology·Robert D HoeldtkeUNKNOWN DCCT Research Group
Jan 8, 2017·Muscle & Nerve·Andrew McKeon, Jennifer A Tracy
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·R D HoeldtkeA Lernmark
Jun 9, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Giulia FerranniniAnna Norhammar

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