Phospholipid antibodies and resistance to activated protein C in women with thrombophilia

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
M I BokarewaK Bremme

Abstract

Seventy-eight women with a history of thromboembolism were studied for cardiolipin antibodies (CLa), lupus anticoagulant activity (LA) and resistance to activated protein C (APC-resistance). Elevated CLa were found in 15 (19%) and LA in 15 women (19%), respectively. Twenty-six patients (33%) were APC-resistant, 17 of them had LA and/or CLa. No correlation was observed between the LA coefficient, CLa level and the extent of APC-resistance. The study shows the difference in the nature of phospholipid antibodies (PLa) and APC-resistance: cause-dependent for APC-resistance and time-dependent for the LA activity. APC-resistance was commoner in thrombosis triggered by endogenous (pregnancy, delivery) than by exogenous (oral contraceptives, surgery) factors (P < 0.05). The incidence of PLa was not connected to the cause of thrombosis. Time-dependent changes in the PLa spectrum manifested by a reduction of isolated LA frequency five years after thrombosis (P < 0.05). The response of APC seemed to show no variation with time passed after thrombosis. The co-existence of PLa and APC-resistance in 22% of thrombophilic women may stress the role of phospholipids in the blood coagulation process.

Citations

Dec 16, 1998·Australian and New Zealand Journal of Medicine·J Grant
Sep 1, 1995·The Journal of Laboratory and Clinical Medicine·M I BokarewaK Bremme
Aug 1, 1997·The Journal of Laboratory and Clinical Medicine·J AznarC Falcó
Jan 12, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·N DayanV Tagalakis
Aug 15, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Chris GardinerIan J Mackie

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