(Phospho)lipid-based Nanosystems for Skin Administration

Current Pharmaceutical Design
Željka VanićNataša Škalko-Basnet

Abstract

Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability to assure the controlled drug release to the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate lipid-based nanosystems and micro- and nano-emulsions are discussed in more details. Extensive research in preclinical studies has shown that numerous parameters including the composition, size, surface properties and their combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment, skin oncology, gene delivery and vaccines. We addressed the...Continue Reading

Citations

Mar 10, 2017·Drug Development and Industrial Pharmacy·Saman HeydariHamed Hamishehkar
May 28, 2016·Pharmaceutics·Zora Rukavina, Željka Vanić
May 10, 2019·Journal of Microencapsulation·Çiğdem Yücelİsmail Tuncer Değim
Oct 5, 2019·Current Pharmaceutical Design·Elisabetta EspositoRita Cortesi
May 12, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nur Najihah Izzati Mat RaniMohd Cairul Iqbal Mohd Amin
Jun 3, 2021·Marine Drugs·Lisa Myrseth HemmingsenNataša Škalko-Basnet
Jul 3, 2021·Expert Opinion on Drug Delivery·Ana Cláudia Paiva-SantosFrancisco Veiga
Aug 8, 2021·International Journal of Molecular Sciences·Maddalena SguizzatoRita Cortesi
Apr 22, 2020·ACS Applied Materials & Interfaces·Samuel C T MoorcroftStephen D Evans

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