Phospholipid bilayer-coated aluminum nanoparticles as an effective vaccine adjuvant-delivery system

ACS Applied Materials & Interfaces
Ting WangNing Wang

Abstract

The phospholipid bilayer-coated aluminum nanoparticles (PLANs), formed via chemisorption, were prepared by reverse ethanol injection-lyophilization (REIL) utilizing the phosphophilicity of aluminum. The anhydrous antigen-loaded PLANs obtained by REIL proved stable, satisfying using the controlled-temperature-chain instead of the integrated cold-chain for distribution, and could be rehydrated to reconstitute instantly an aqueous suspension of the antigen-PLANs, which were more readily taken up by antigen-presenting cells and, when given subcutaneously to mice, induced more robust antigen-specific humoral and cellular immunoresponses but less local inflammation than the antigen-alum. Thus, the PLANs are a useful vaccine adjuvant-delivery system with advantages over the widely used naked alum.

References

Feb 22, 2005·Methods in Enzymology·Leila Zarif
Feb 24, 2006·Nature Reviews. Immunology·Marian R Neutra, Pamela A Kozlowski
Oct 13, 2007·Expert Review of Vaccines·Nathalie GarçonMarcelle Van Mechelen
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arnaud M DidierlaurentNathalie Garçon
Feb 16, 2010·Trends in Immunology·Christopher ExleyHåkan Eriksson
Oct 2, 2012·Journal of Liposome Research·Philippe GentineBenoît Frisch
Jan 15, 2013·ChemMedChem·Peter Michael Moyle, Istvan Toth
Jul 6, 2013·Science·Mitch Leslie
Dec 7, 2013·Nature Medicine·Steven G ReedChristopher B Fox
Apr 29, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ning WangYihui Deng
Jun 14, 2014·Nature Reviews. Immunology·Ennio De Gregorio, Rino Rappuoli

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Citations

Apr 21, 2016·ACS Medicinal Chemistry Letters·Xiangqian JiaZhiyuan Hu
Nov 27, 2016·Journal of Biomaterials Applications·Xiaoyan WangZonghua Liu
Feb 27, 2019·Nanomedicine·Ru WenAmmad Ahmad Farooqi
Sep 15, 2020·Pediatric Research·Dheeraj SoniDavid J Dowling
Jun 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Viktoriya SokolovaMatthias Epple
Sep 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bingbing Sun, Tian Xia
May 13, 2020·Journal of Inorganic and Organometallic Polymers and Materials·Ning WangTing Wang
Mar 17, 2021·Expert Review of Vaccines·Yizhi Qi, Christopher B Fox
Nov 28, 2018·ACS Applied Materials & Interfaces·Yingli ChenFenglin Lv

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