Phospholipid-Block Copolymer Hybrid Vesicles with Lysosomal Escape Ability

Langmuir : the ACS Journal of Surfaces and Colloids
Wei ZongBrigitte Städler

Abstract

The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization, and intracellular location. Vesicular assemblies consisting of phospholipids and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes while overcoming their challenges. We report the synthesis of poly(cholesteryl methacrylate)- block-poly(2-(dimethylamino) ethyl methacrylate) (pCMA- b-pDMAEMA) block copolymers and their assembly with phospholipids into hybrid vesicles. Their geometry, their ζ-potential, and their ability to adsorb onto polymer-coated surfaces were assessed. Giant unilamellar vesicles were employed to confirm the presence of both the phospholipids and the block copolymer in the same membrane. Furthermore, the cytotoxicity of selected hybrid vesicles was determined in RAW 264.7 mouse macrophages, primary rat Kupffer cells, and human macrophages. The internalization and lysosomal escape ability of the hybrid vesicles were confirmed using RAW 264.7 mouse macrophages. Taken together, our findings illustrate that the reported hybrid vesicles are a promising complementary drug delivery platform for existing liposomes and polymer...Continue Reading

References

May 31, 2006·Chemical Communications : Chem Comm·Jiehua ZhouLing Peng
Jun 4, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Sagar A PanditH L Scott
Jun 22, 2010·Current Opinion in Biotechnology·Sheereen MajdMichael Mayer
Nov 17, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amir K VarkouhiHidde J Haisma
Apr 12, 2011·Biomacromolecules·Nghia P TruongMichael J Monteiro
Sep 9, 2011·Bioconjugate Chemistry·Zhiliang ChengAndrew Tsourkas
Jul 28, 2012·Chemical Communications : Chem Comm·Johannes ThomaWolfgang Meier
Nov 23, 2012·Nanoscale·Leticia Hosta-RigauBrigitte Städler
Jan 3, 2013·Angewandte Chemie·Matthias SchulzWolfgang H Binder
Dec 24, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Adekunle OlubummoWolfgang H Binder
Apr 16, 2014·Journal of Nanoscience and Nanotechnology·Harshad K SheteVandana B Patravale
Jul 30, 2014·Biomacromolecules·Anja CarWolfgang Meier
Oct 8, 2014·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Nov 21, 2014·Advances in Genetics·Patrick Neuberg, Antoine Kichler
Dec 3, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Ying WangSiling Wang
Dec 23, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Elizabeth J AdolphCraig L Duvall
Apr 8, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Justyna KowalWolfgang Meier
May 27, 2015·Chemical Reviews·Bhushan S PattniVladimir P Torchilin
Sep 5, 2015·Biomicrofluidics·Karthiga PanneerselvamBrigitte Städler
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Sep 12, 2015·Expert Opinion on Drug Delivery·Aditi Jhaveri, Vladimir Torchilin
Oct 13, 2015·Macromolecular Rapid Communications·Matthias Schulz, Wolfgang H Binder
May 19, 2016·ACS Applied Materials & Interfaces·Jia LiuLin Wang
Aug 16, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Natassa PippaBarbara Trzebicka
Oct 26, 2016·Nature Materials·Kim M TsoiWarren C W Chan
Aug 20, 2016·Chemical Communications : Chem Comm·Sanobar KhanPaul A Beales
Aug 12, 2017·Colloids and Surfaces. B, Biointerfaces·Walter F PaxtonHaley L Monteith
Dec 13, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Mudassar Mumtaz Virk, Erik Reimhult
Jan 30, 2018·Advanced Science·Ariane PeyretSebastien Lecommandoux
Feb 8, 2018·Methods : a Companion to Methods in Enzymology·Rashmi SeneviratnePaul A Beales
Jan 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Arti VashistSharif Ahmad

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Citations

May 13, 2020·Physical Chemistry Chemical Physics : PCCP·Claire E MeyerCornelia G Palivan
May 1, 2019·Advanced Biosystems·Federico Mazur, Rona Chandrawati
May 30, 2020·Small·Edit BrodszkijBrigitte Städler
Apr 10, 2020·Biochimica Et Biophysica Acta. General Subjects·Ylenia MieleFederico Rossi
Nov 19, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xiaomin QianBrigitte Städler
Aug 17, 2018·ACS Applied Materials & Interfaces·Fabian ItelBrigitte Städler
Aug 24, 2021·Biomacromolecules·Paula De Dios AndresBrigitte Städler
Apr 23, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Jamuna K Vaishnav, Tushar Kanti Mukherjee
Jan 13, 2022·Biomacromolecules·Carina AdeBrigitte Städler

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