Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba

Brain Research
Jochen KleinK Löffelholz

Abstract

A marked increase of choline release from rat hippocampal slices was observed when the slices were superfused with oxygen-free buffer, indicating hypoxia-induced hydrolysis of choline-containing phospholipids. This increase of choline release was suppressed by bilobalide, an ingredient of Ginkgo biloba, but not by a mixture of ginkgolides. The EC50 value for bilobalide was 0.38 microM. In ex vivo experiments, bilobalide also inhibited hypoxia-induced choline release when given p.o. in doses of 2-20 mg/kg 1 h prior to slice preparation. The half-maximum effect was observed with 6 mg/kg bilobalide. A similar effect was noted after p.o. administration of 200 mg/kg EGb 761, a ginkgo extract containing approximately 3% of bilobalide. We conclude that ginkgo extracts can suppress hypoxia-induced membrane breakdown in the brain, and that bilobalide is the active constituent for this effect.

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Citations

May 25, 2013·Clinical Pharmacokinetics·Christian UdeMario Wurglics
Dec 1, 2006·Brain Research·Cornelia KiewertJochen Klein
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hiroyasu Satoh, Seiichiro Nishida
Apr 15, 2004·Neurochemistry International·Y S KwonH C Kim
Nov 8, 2001·European Journal of Pharmacology·B AhlemeyerJ Krieglstein
Aug 10, 2002·Progress in Neurobiology·Karyn M MaclennanPaul F Smith
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Zahoor Ahmad ShahS B Vohora
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Feb 19, 2009·The Journal of Pharmacology and Experimental Therapeutics·Roger L PapkeNicole A Horenstein
Jan 5, 2007·Biological & Pharmaceutical Bulletin·Wei-Dong ChenGuang-Ji Wang
Apr 23, 2005·Neurological Research·Hocheol Kim
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Oct 26, 2002·Journal of Natural Products·Dirk LichtblauKoji Nakanishi

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