Phospholipid composition controls thromboplastin sensitivity to individual clotting factors.

Journal of Thrombosis and Haemostasis : JTH
S A SmithJ H Morrissey

Abstract

Tissue factor is the active ingredient in thromboplastin reagents used to perform prothrombin time (PT) clotting tests to monitor oral anticoagulant therapy and to screen for clotting factor deficiencies. Thromboplastins are complex mixtures prepared from extracts of brain or placenta, although newer thromboplastins contain recombinant tissue factor incorporated into phospholipid vesicles. Thromboplastins can vary widely in their sensitivity to reductions in the levels of vitamin K-dependent clotting factors. A system to compensate for this, the International Sensitivity Index (ISI) and International Normalized Ratio (INR), has revolutionized the monitoring of oral anticoagulant therapy. The INR system is also sometimes used to monitor coagulopathies in patients with sepsis or liver failure, applications for which it was not originally designed and for which it has not been rigorously validated. To better understand thromboplastin performance, we systematically investigated which properties of recombinant thromboplastins influence their sensitivities to changes in the levels of specific clotting factors. We now report that relative sensitivities to changes in the plasma levels of factors V, VII, X (FV, FVII, FX) and prothrombin...Continue Reading

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Jun 29, 2004·Journal of Thrombosis and Haemostasis : JTH·S A Smith, J H Morrissey
Aug 31, 2004·Journal of Thrombosis and Haemostasis : JTH·S A Smith, J H Morrissey

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Citations

May 18, 2012·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Randolph L WinterE Christopher Orton
Aug 12, 2009·Clinics in Laboratory Medicine·Valerie L Ng
Jul 15, 2006·Journal of Thrombosis and Haemostasis : JTH·S A SmithJ H Morrissey
Apr 21, 2010·Journal of Thrombosis and Haemostasis : JTH·J H H Van Geest-DaalderopA M H P Van Den Besselaar
Sep 13, 2014·International Journal of Laboratory Hematology·Kenny M HanssonJohanna Deinum
Oct 26, 2016·Journal of Veterinary Emergency and Critical Care·Trevor P E WilliamsLarry Berkwitt
Jun 23, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Barbara Depreter, Katrien M J Devreese
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Mar 9, 2019·Veterinary Medicine and Science·Liam A EvansReid K Nakamura
Mar 8, 2016·Anesthesiology·Daniel DirkmannJürgen Peters
Jun 17, 2020·British Journal of Haematology·Peter BakerUNKNOWN British Society for Haematology, Haemostasis and Thrombosis Task Force
Oct 19, 2020·International Journal of Laboratory Hematology·Mariarosa CartaDavide Giavarina
Jan 19, 2021·International Journal of Laboratory Hematology·Minjeong NamYeo-Min Yun

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