PMID: 16517957Mar 7, 2006Paper

Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil

JPEN. Journal of Parenteral and Enteral Nutrition
Makoto UsamiYuri Fueda

Abstract

Irinotecan hydrochloride (CPT-11), a topoisomerase I inhibitor highly effective for various cancers, has its dosage limited by diffuse mucosal damage with increased prostaglandin (PG) E(2). However, an analysis of intestinal phospholipid fatty acid composition after CPT-11 treatment has not been reported. This study aimed to evaluate intestinal phospholipid fatty acid composition in relation to intestinal mucosal integrity and plasma and mucosal PGE(2) levels after CPT-11 treatment. The effect of dietary vegetable oil supplementation, perilla oil vs corn oil, was also evaluated. Intestinal phospholipid fatty acid composition, PGE(2) level, mucosal diamine oxidase (DAO) activity, diarrhea, and blood tests were evaluated in rats injected with CPT-11 under a conventional diet. The same parameters were compared among 3 different dietary vegetable oil supplementations: perilla oil, corn oil, and a 1:3, respectively, mixture with a semisynthetic diet during 14 days. CPT-11 treatment caused severe diarrhea, and intestinal mucosal fatty acid composition changed with increased PGE(2) level and decreased DAO activity. Decreases in eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and EPA/arachidonic acid (AA) ratio in colonic muco...Continue Reading

References

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Mar 3, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·U N DasP Sangeetha
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Citations

Apr 29, 2009·World Journal of Gastroenterology : WJG·Jun LiuChuan-Yong Guo
Feb 14, 2009·Journal of Gastroenterology·Kenichi IshiiHideki Fujii
Oct 27, 2012·Clinical Biochemistry·Yasuhiro HamadaMakoto Usami
Feb 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Alexander H Penn, Geert W Schmid-Schönbein

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