Phospholipid homeostasis in phosphatidylserine synthase-2-deficient mice

Biochimica Et Biophysica Acta
Rineke SteenbergenJean E Vance

Abstract

Phosphatidylserine (PS) is synthesized in mammalian cells by two distinct serine-exchange enzymes, phosphatidylserine synthase-1 and -2. We recently demonstrated that mice lacking PS synthase-2 develop normally and exhibit no overt abnormalities [Bergo et al., (2002) J. Biol. Chem. 277:47701-47708]. We now show that PS synthase-2 mRNA levels are up to 80-fold higher in livers of embryos than in adults. Despite reduced serine-exchange activity in several tissues of PS synthase-2 deficient mice, the phospholipid composition of mitochondria and microsomes from these tissues is normal. Although PS synthase-2 is highly expressed in neurons, axon extension of cultured sympathetic neurons is not impaired by PS synthase-2 deficiency. We hypothesized that mice compensate for PS synthase-2 deficiency by modifying their phospholipid metabolism. Our data show that the rate of PS synthesis in hepatocytes is not reduced by PS synthase-2 deficiency but PS synthase-1 activity is increased. Moreover, PS degradation is decreased by PS synthase-2 deficiency, probably as a result of decreased PS degradation via phospholipases rather than decreased PS decarboxylation. These experiments underscore the idea that cellular phospholipid composition is t...Continue Reading

Citations

Jul 25, 2009·The Journal of Biological Chemistry·Morgan D FullertonMarica Bakovic
Nov 12, 2010·The Journal of Biological Chemistry·Guergana TassevaJean E Vance
Dec 21, 2012·Journal of the Royal Society, Interface·Marcus K DymondGeorge S Attard
Mar 12, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tânia SousaS A L M Kooijman
Oct 6, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tânia SousaS A L M Kooijman
Oct 29, 2008·Journal of Lipid Research·Dennis E Vance, Jean E Vance
Mar 9, 2011·Progress in Lipid Research·Martin HermanssonPentti Somerharju
Jan 15, 2011·The FEBS Journal·Mauro Serricchio, Peter Bütikofer
May 15, 2013·The Journal of Animal Ecology·James L MainoSebastiaan A L M Kooijman
Sep 27, 2012·Biochimica Et Biophysica Acta·Luce Farine, Peter Bütikofer
Sep 11, 2012·Biochimica Et Biophysica Acta·Jean E Vance, Guergana Tasseva
Jul 6, 2014·Progress in Lipid Research·Hee-Yong KimArthur A Spector
Sep 7, 2013·Progress in Lipid Research·Susanne E Horvath, Günther Daum
Jul 5, 2016·Biological & Pharmaceutical Bulletin·Fuka AizawaShogo Tokuyama
Jul 13, 2006·Journal of Lipid Research·Karen Reue, Laurent Vergnes
Jul 7, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marica BakovicVera Michel
Aug 30, 2008·Endocrinology·Sonja E GustinAndrew H Sinclair
Mar 18, 2008·The Journal of Biological Chemistry·Devi ArikkethJean E Vance

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.