PMID: 6965797Feb 1, 1980Paper

Phospholipid methylation: a biochemical signal modulating lymphocyte mitogenesis

Proceedings of the National Academy of Sciences of the United States of America
F HirataM J Waxdal

Abstract

Phospholipid methylation in murine T lymphocytes but not B cells was stimulated by mitogenic lectins such as concanavalin A and phytohemagglutinin, and the methylation was then returned to the control level by the concomitant activation of phospholipase A2. A parallelism between dose-response curves of concanavalin A for phospholipid methylation and thymidine incorporation was found. Inhibition of either synthesis or degradation of methylated phospholipids resulted in a decrease in the thymidine incorporation. Although prostaglandins such as the E and F series were the main products of arachidonic acid released by phospholipase A2 activation, inhibition of synthesis of these compounds by indomethacin did not reduce the thymidine incorporation significantly. These results suggest that the mitogenesis of murine T lymphocytes is triggered by the activation of both phospholipid methyltransferase(s) and phospholipase A2.

References

May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W T ShierN M Thanassi
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T P ZimmermanG S Duncan
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F Hirata, J Axelrod
May 17, 1976·Biochemical and Biophysical Research Communications·C BonaE Lederer

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Citations

Jan 1, 1985·Archives of Dermatological Research·Y Niwa, Y Miyachi
Dec 1, 1982·Agents and Actions·A T Ali, J Morley
Jun 1, 1982·Clinical Rheumatology·J P Famaey
Nov 23, 1983·Biochimica Et Biophysica Acta·R K JaiswalB V Sastry
Jul 15, 1983·Biochemical Pharmacology·D J FellerD B Bylund
Jan 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·P FonluptH Pachéco
Dec 1, 1987·European Journal of Pharmacology·Y MatsuiN Iwata
Mar 1, 1982·Molecular Immunology·S ToyoshimaM J Waxdal
Oct 1, 1987·Immunology Letters·J SzelényiS Hollán
Jun 25, 1984·Biochimica Et Biophysica Acta·S L Pelech, D E Vance
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P MallorgaJ Axelrod
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T HoffmanJ Axelrod
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·V Y HookJ Axelrod
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C E LeprohonR J Wurtman
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J J Sando, M C Young
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A de BlasM Nirenberg
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F HirataR del Carmine
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K L KellyL Jarett
Jun 1, 1993·Journal of Neuroimmunology·H B SolvasonR N Hiramoto
Sep 1, 1980·Neurochemical Research·F T CrewsJ Axelrod
Nov 28, 1980·Biochemical and Biophysical Research Communications·T D Gelehrter, E Rozengurt

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