PMID: 2125819Dec 1, 1990Paper

Phospholipid peroxidation induced by the catechol-Fe3+(Cu2+) complex: a possible mechanism of nigrostriatal cell damage

Archives of Biochemistry and Biophysics
A SotomatsuS Hirai

Abstract

Ferric or cupric ions significantly promoted a peroxidative cleavage of unsaturated phospholipids in liposomes in vitro after coordinating with dopa and dopamine. Either alpha-tocopherol or desferrioxamine completely abolished the dopa-Fe3+ complex-induced phospholipid peroxidation, while superoxide dismutase, catalase, or sodium benzoate did not. A ferroxidase, ceruloplasmin, significantly inhibited the lipid peroxidation induced by the dopa-Fe3+ complex, indicating the importance of the reduction of the iron moiety in the complex for the lipid peroxidation. A possible mechanism of dopa-Fe3+ complex-induced phospholipid peroxidation is that oxene complexes, such as Fe(V) = O and Fe(IV) = O, produced abstract hydrogen atoms in unsaturated phospholipids to initiate lipid peroxidation.

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Citations

Sep 18, 2008·Molecular Genetics and Genomics : MGG·Christian Q Scheckhuber, Heinz D Osiewacz
Feb 1, 1991·Journal of the Neurological Sciences·M TanakaS Hirai
Feb 1, 1996·The International Journal of Biochemistry & Cell Biology·E CasalinoC Landriscina
Jan 24, 2004·Life Sciences·Sanae Muraoka, Toshiaki Miura
Oct 31, 2000·Journal of the Neurological Sciences·B C WhiteG S Krause
Jan 21, 2000·Free Radical Biology & Medicine·N HoshinoT Ando
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Oct 2, 2001·Bioscience, Biotechnology, and Biochemistry·H YoshiokaF Hayakawa
Dec 31, 2010·Dose-response : a Publication of International Hormesis Society·Subhendu MukherjeeDipak K Das
Jun 2, 2009·International Journal of Pharmaceutics·Xiaowei LuXirong Guo
Jan 18, 2006·Bioorganic & Medicinal Chemistry·Mahesh SubramanianSubrata Chattopadhyay
Aug 26, 1998·Biochemical Pharmacology·T MiuraT Ogiso

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