PMID: 8944224Jan 1, 1996Paper

Phospholipid-rich particles in commercial parenteral fat emulsions. An overview

Progress in Lipid Research
A C BachA Frey

Abstract

In parenteral nutrition, the infusion of a fat EMU supplies both concentrated energy and covers the essential fatty acid requirements, the basic objective being to mimic as well as possible the input of chylomicrons into the blood. This objective is well met by the TAGRP of the EMU, which behave as true chylomicrons. However, commercial EMU also contain an excess of emulsifier in the form of PLRP. The number of these PLRP depends directly on the PL/TAG ratio of the EMU. They differ from the TAGRP by their composition (PL vs TAG and PL), their structure (PL in bilayer versus monolayer), and their granulometry (mean diameter 70-100 nm for PL vs 200-500 nm). The metabolic fate of the PLRP is similar in several ways to that of the TAGRP: exchanges of PL with the PL of the different cellular membranes and of the lipoproteins; captation of free CH from these same structures; and enrichment in apolipoproteins. However, because the TAGRP are the preferred substrates of the lipolytic enzymes, their clearance is much more rapid (half-life < 1 h) than that of the PLRP. As the infusion is continued, the PLRP end up accumulating and being transformed into LP-X (free CH/PL = 1; half-life of several days). As soon as the EMU is infused, the P...Continue Reading

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Citations

Jun 11, 1999·International Journal of Pharmaceutics·C VermehrenS Frokjaer
Dec 18, 2001·Nutrition·J FérézouA C Bach
Feb 26, 2000·Clinics in Perinatology·G Putet
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May 27, 2009·Drug Development and Industrial Pharmacy·Yan LiuXing Tang
Jun 29, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Dan L WaitzbergThiago Manzoni Jacintho
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Jul 9, 2008·Journal of Microencapsulation·Xiaoliang LiuHongyao Zhang
Jul 14, 2010·Journal of Colloid and Interface Science·Judith KuntscheHeike Bunjes

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