PMID: 8606364Nov 1, 1995Paper

Phospholipid surface density determines the partitioning and permeability of acetic acid in DMPC:cholesterol bilayers

The Journal of Membrane Biology
T X Xiang, B D Anderson

Abstract

Relationships between the permeability coefficient (PHA) and partition coefficient (K m/w) of acetic acid and the surface density of DMPC:cholesterol bilayers have been investigated. Permeability coefficients were measured in large unilamellar vesicles by NMR line broadening. Bilayer surface density, sigma, was varied over a range of 0.5-0.9 by changing cholesterol concentration and temperature. The temperature dependence of PHA for acetic acid exhibits Arrhenius behavior with an average apparent activation energy (Ea) of 22 +/- 3 kcal/mole over a cholesterol mole fraction range of 0.00-0.40. This value is much greater than the enthalpy change for acetic acid partitioning between bulk decane and water (delta H degree = 4.8 +/- 0.8 kcal/mole) and the calculated Ea (= 8.0 kcal/mole) assuming a "bulk phase" permeability model which includes the enthalpy of transfer from water to decane and the temperature dependence of acetic acid's diffusion coefficient in decane. These results suggest that dehydration, previously considered to be a dominant component, is a minor factor in determining Ea. Values of 1n PHA decrease linearly with the normalized phospholipid surface density with a slope of kappa = -12.4 +/- 1.1 (r = 0.90). Correctio...Continue Reading

Citations

Mar 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Mitragotri
May 25, 2012·Journal of Chemical Information and Modeling·Siegfried S F LeungMatthew P Jacobson
Sep 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·John M A GrimePatrick R Unwin
Jan 2, 2008·The Journal of General Physiology·John C MathaiMark L Zeidel
Jan 2, 2008·The Journal of General Physiology·John F NagleStephanie Tristram-Nagle
Nov 10, 2006·Advanced Drug Delivery Reviews·Tian-Xiang Xiang, Bradley D Anderson
Nov 8, 2012·Journal of Pharmaceutical Sciences·Johannes M Nitsche, Gerald B Kasting
Mar 10, 2016·Chemistry and Physics of Lipids·Waldemar KuligIlpo Vattulainen
Jul 5, 1997·Biochimica Et Biophysica Acta·S M DavidsonA S Janoff
Jun 17, 2008·Journal of Pharmaceutical Sciences·Costas Giaginis, Anna Tsantili-Kakoulidou
Mar 22, 2014·Soft Matter·Dandan SunNing Gu
Jun 7, 2017·Physical Biology·Panagiotis E TheodorakisOmar K Matar
Nov 18, 2004·Journal of Lipid Research·Kellen BrunaldiJoaquim Procopio
Mar 7, 2009·Chemical Reviews·Stefan Balaz
Jul 17, 1996·Journal of the American Chemical Society·M A Wilson, A Pohorille
Apr 30, 2021·Molecular Pharmaceutics·Mohammad Sharifian Gh
May 2, 1998·Biochimica Et Biophysica Acta·T X Xiang, B D Anderson
Jun 5, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·Q YangJ Miyake
Jan 16, 1999·Biochimica Et Biophysica Acta·R G Males, F G Herring
Apr 13, 2006·Chemical Reviews·Kenneth B Eisenthal
Mar 1, 2012·Journal of the American Chemical Society·Christian L WennbergJochen S Hub
Feb 14, 2018·The Journal of Physical Chemistry Letters·Waldemar KuligTomasz Rog
Aug 14, 2019·ACS Nano·Changjiang LiuAngela Violi
Aug 18, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Agnieszka OlzynskaIlpo Vattulainen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.