Phospholipid transfer protein deficiency ameliorates diet-induced hypercholesterolemia and inflammation in mice.

Journal of Lipid Research
Lorraine ShellyYi Luo

Abstract

Phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids from triglyceride-rich lipoproteins into HDL. PLTP has been shown to be an important factor in lipoprotein metabolism and atherogenesis. Here, we report that chronic high-fat, high-cholesterol diet feeding markedly increased plasma cholesterol levels in C57BL/6 mice. PLTP deficiency attenuated diet-induced hypercholesterolemia by dramatically reducing apolipoprotein E-rich lipoproteins (-88%) and, to a lesser extent, LDL (-40%) and HDL (-35%). Increased biliary cholesterol secretion, indicated by increased hepatic ABCG5/ABCG8 gene expression, and decreased intestinal cholesterol absorption may contribute to the lower plasma cholesterol in PLTP-deficient mice. The expression of proinflammatory genes (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) is reduced in aorta of PLTP knockout mice compared with wild-type mice fed either a chow or a high-cholesterol diet. Furthermore, plasma interleukin-6 levels are significantly lower in PLTP-deficient mice, indicating reduced systemic inflammation. These data suggest that PLTP appears to play a proatherogenic role in diet-induced hyperlipidemic mice.

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Citations

Nov 26, 2009·The Journal of Pharmacology and Experimental Therapeutics·Yi LuoXian-Cheng Jiang
Jul 25, 2009·Lipids in Health and Disease·Ryan J HendersonCarlos G Leon
Dec 2, 2009·Nutrition & Metabolism·Xueying ChenXian-Cheng Jiang
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Jan 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·David MassonLaurent Lagrost
Jan 27, 2021·Current Atherosclerosis Reports·Xian-Cheng Jiang, Yang Yu

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