PMID: 9182690Jun 1, 1997Paper

Phospholipid transfer proteins revisited

The Biochemical Journal
K W Wirtz

Abstract

Phosphatidylinositol transfer protein (PI-TP) and the non-specific lipid transfer protein (nsL-TP) (identical with sterol carrier protein 2) belong to the large and diverse family of intracellular lipid-binding proteins. Although these two proteins may express a comparable phospholipid transfer activity in vitro, recent studies in yeast and mammalian cells have indicated that they serve completely different functions. PI-TP (identical with yeast SEC14p) plays an important role in vesicle flow both in the budding reaction from the trans-Golgi network and in the fusion reaction with the plasma membrane. In yeast, vesicle budding is linked to PI-TP regulating Golgi phosphatidylcholine (PC) biosynthesis with the apparent purpose of maintaining an optimal PI/PC ratio of the Golgi complex. In mammalian cells, vesicle flow appears to be dependent on PI-TP stimulating phosphatidylinositol 4,5-bisphosphate (PIP2) synthesis. This latter process may also be linked to the ability of PI-TP to reconstitute the receptor-controlled PIP2-specific phospholipase C activity. The nsL-TP is a peroxisomal protein which, by its ability to bind fatty acyl-CoAs, is most likely involved in the beta-oxidation of fatty acids in this organelle. This protein...Continue Reading

Citations

Nov 21, 2007·The Journal of Cell Biology·Petra BaumgärtnerBernd Engelmann
Nov 12, 2015·ACS Chemical Biology·Per HaberkantCarsten Schultz
Jun 19, 2009·Advances in Enzyme Regulation·David L Mellman, Richard A Anderson
Jun 5, 2007·Biochimica Et Biophysica Acta·Friedhelm SchroederAnn B Kier
Feb 27, 2007·Biochimica Et Biophysica Acta·Rhoderick E Brown, Peter Mattjus
Jul 19, 2008·Traffic·Sadaf ShadanShamshad Cockcroft
Jan 27, 2010·The Journal of General Physiology·Björn H FalkenburgerBertil Hille
Feb 15, 2005·Biochimica Et Biophysica Acta·Martina SchnablHarald Pichler
Feb 4, 2006·Critical Reviews in Biochemistry and Molecular Biology·Scott E PhillipsEric A Gaucher
Aug 10, 2011·Current Opinion in Microbiology·Paul B Lazarow
Aug 26, 1998·Biochimica Et Biophysica Acta·E C GaynorS D Emr
Jul 21, 2006·Advances in Enzyme Regulation·Karel W A WirtzPiet Gros
Aug 18, 2001·Biophysical Journal·K TanhuanpääP Somerharju
Sep 7, 2005·Animal Reproduction Science·T E HutchinsonB M J Pereira
Jul 1, 1999·Protein Science : a Publication of the Protein Society·G BoissyS Brunie
Jul 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Cockcroft
Oct 10, 2001·Progress in Lipid Research·A M GallegosF Schroeder
Jun 17, 2006·Cellular and Molecular Neurobiology·Małgorzata ChalimoniukJoanna B Strosznajder
Aug 27, 2004·Nature·Lucy MalininaDinshaw J Patel
Nov 30, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Annamária KakukGyörgy Vereb
Oct 29, 2002·FEBS Letters·Victoria Allen-BaumeShamshad Cockcroft
Oct 20, 2006·Nature Chemical Biology·Kristina E IleVytas A Bankaitis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.