Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects

Bioconjugate Chemistry
Ekaterina S ShchegravinaI A Boldyrev

Abstract

Enzyme-responsive liposomes release their cargo in response to pathologically increased levels of enzymes at the target site. We report herein an assembly of phospholipase A2-responsive liposomes based on colchicinoid lipid prodrugs incorporated into lipid bilayer of the nanosized vesicles. The liposomes were constructed to addresses two important issues: (i) the lipid prodrugs were designed to fit the structure of the enzyme binding site; and (ii) the concept of lateral pressure profile was used to design lipid prodrugs that introduce almost no distortions into the lipid bilayer packing, thus ensuring that corresponding liposomes are stable. The colchicinoid agents exhibit antiproliferative activity in subnanomolar range of concentrations.

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Citations

Sep 6, 2020·International Journal of Molecular Sciences·Gengqi LiuYumiao Zhang
May 21, 2020·Journal of Medicinal Chemistry·Iuliia A GrachevaAlexey Yu Fedorov
Apr 3, 2021·Frontiers in Oncology·Marina Santiago FrancoMônica Cristina Oliveira
Jun 22, 2021·ACS Pharmacology & Translational Science·Nour AlSawaftahGhaleb A Husseini
Dec 18, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Chao WangWeige Zhang
Oct 2, 2020·International Journal of Pharmaceutics·Jiang YuYongjun Wang

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