Phosphonate-modified Gd-DTPA complexes. III: The detection of myocardial infarction by MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
I K AdzamliM A Davis

Abstract

The potential of a phosphonate-modified-Gd-DTPA for MR image enhancement of myocardial infarction has been demonstrated in imaging experiments on rats. The agent, 1-hydroxy-3-aminopropane-1,1-diphosphonate-modified-Gd-DTPA (Gd-DTPA-HPDP) accumulates in two models of myocardial infarction, (i.e., drug-induced diffusely infarcted whole hearts and in focal acute myocardial infarction from a left coronary artery ligation). The time course of the accumulation of the agent in the focal model of infarction and subsequent washout has also been followed in vitro. Results of this kinetics demonstrate that the agent first perfuses all normal fluid spaces and then slowly diffuses into the occluded zone where it is retained for a prolonged period, in sufficient quantities to be useful as an MRI contrast agent. Wash-out of the agent from normal myocardium is fast and complete with MR signal returning to background in minutes. The specificity of Gd-DTPA-HPDP for soft-tissue calcification and its retention within the infarcts permitted imaging at 1 to 2 h postinjection, (after unbound material has cleared the normal tissues). Infarcted tissue appeared as regions of increased signal intensity in T1-weighted images (> 200% enhancement), and corr...Continue Reading

References

Apr 1, 1979·Circulation Research·M A PfefferE Braunwald
Jan 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·H K Lee, O Nalcioglu
Nov 1, 1991·Investigative Radiology·M F WendlandC B Higgins
Apr 1, 1991·Investigative Radiology·R M Slone
Jan 1, 1991·Magnetic Resonance Imaging·J Kahn, M R Fisher
Jan 1, 1991·Magnetic Resonance Imaging·S M HammersmithL J Haywood
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N A MatheijssenA E van Voorthuisen
Jan 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I K Adzamli, M Blau
Mar 1, 1990·Radiology·D J AtkinsonR R Edelman
Apr 1, 1988·Radiology·P W PflugfelderC B Higgins
Jun 26, 1986·The New England Journal of Medicine·J Y CheungA Leaf
May 1, 1986·The American Journal of Cardiology·D L JohnstonR D Okada
Jan 1, 1985·The Journal of Membrane Biology·A Elgavish, G A Elgavish

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Citations

Nov 5, 1999·Journal of Magnetic Resonance Imaging : JMRI·T H Lim, S I Choi
Aug 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A KovarG S Karczmar
Jun 6, 2000·Advanced Drug Delivery Reviews·Y Okuhata
Nov 1, 2003·Academic Radiology·Robert E LenkinskiS Nahum Goldberg
Jul 19, 2005·Investigative Radiology·Yicheng NiGuy Marchal
Mar 24, 2011·Future Medicinal Chemistry·Vojtěch Kubíček, Ivan Lukeš
Dec 26, 2001·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·A K JeongT H Lim
Nov 25, 2005·Journal of the American Chemical Society·Vojtech KubícekIvan Lukes

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