PMID: 195514May 1, 1977

Phosphonoacetic acid-resistant mutants of herpes simplex virus: effect of phosphonoacetic acid on virus replication and in vitro deoxyribonucleic acid synthesis in isolated nuclei

Antimicrobial Agents and Chemotherapy
Y BeckerJ Shlomai

Abstract

Phosphonoacetic acid (PAA) inhibits the replication of herpes simplex virus in BSC-1 cells and the in vitro synthesis of deoxyribonucleic acid (DNA) in isolated nuclei. Phosphonopropionic acid at a concentration of 100 mug/ml had no effect on herpes simplex virus replication. PAA-resistant mutants were obtained at a rate of 1 in 10(4) plaque-forming units after 5-bromodeoxyuridine mutagenization of the virus. These mutants replicate in BSC-1 cells in the presence of 100 mug of PAA per ml and induce a PAA-resistant DNA polymerase that synthesizes DNA in vitro in the presence of PAA.

References

Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·M Benyesh-MelnickS Kimura
Mar 1, 1975·Antimicrobial Agents and Chemotherapy·D D GersteinJ O O
Feb 1, 1976·Antimicrobial Agents and Chemotherapy·R F MeyerH E Kaufman
Sep 1, 1974·Antimicrobial Agents and Chemotherapy·L R OverbyJ C Mao

Citations

Jan 1, 1979·Pharmacology & Therapeutics·J A Boezi
Jan 1, 1983·Pharmacology & Therapeutics·G Darby, H J Field
Mar 1, 1983·Journal of Virological Methods·B WahrenB Sköldenberg
Apr 1, 1984·Antiviral Research·B A Larder, G Darby
Aug 1, 1985·Antiviral Research·D W Hutchinson
Jan 1, 1981·Pharmacology & Therapeutics·D D Perrin, H Stünzi
Mar 24, 2016·Veterinary Research·Liqian ZhuGuoqiang Zhu
Aug 1, 1977·The British Journal of Ophthalmology·Y J GordonY Becker
Sep 9, 2017·Veterinary Research·Liqian ZhuGuoqiang Zhu

Related Concepts

Acetic Acids
Cell Nucleus
DNA, Double-Stranded
DNA Polymerase N3
DNA, Viral
Antibiotic Resistance, Microbial
Organopyrophosphorus Compounds
Virus Replication
Herpesvirus 16, Cercopithecine

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