Jun 14, 2012

Phosphoproteomics and molecular cardiology: techniques, applications and challenges

Journal of Molecular and Cellular Cardiology
Zeyu SunKenneth F Reardon


Protein phosphorylation has been widely documented as a key regulatory and signaling mechanism associated with many cardiac diseases. Recent advances in phosphoproteomic technologies such as phosphopeptide enrichment, novel mass spectrometry applications, and bioinformatic tools have resulted in high-throughput identification and quantitation of protein phosphorylation in a global manner. This review summarizes mainstream phosphoproteomic workflows and highlights the most recent applications of phosphoproteomics used in a range of molecular cardiology research.

  • References192
  • Citations13


Mentioned in this Paper

Pathologic Cytolysis
Metabolic Process, Cellular
Pathogenic Aspects
Biochemical Pathway
Proteasome Pathway
Phosphoric Monoester Hydrolases
Aluminum Measurement
Cardiology Discipline

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