journal cover

Phosphoproteomics in drug discovery

Drug Discovery Today

Oct 22, 2013

Melody K MorrisLeonidas G Alexopoulos

Abstract

Several important aspects of the drug discovery process, including target identification, mechanism of action determination and biomarker identification as well as drug repositioning, require complete understanding of the effects of drugs on protein phosphorylation in relevant biologica...read more

Mentioned in this Paper

Anaplastic Small Cell Lymphoma
Flow Cytometry
Biochemical Pathway
Procedure to Identify Antibody
Metrorrhagia
Genome
Epidermal Growth Factor Receptor Activity
Protein Phosphorylation
Neoplasms
FRAP1 protein, human
Paper Details
References
  • References54
  • Citations12
12345...
  • References54
  • Citations12
12

Similar Papers Found In These Feeds

Deep Visual Proteomics: Image-Guided Cell Characterization

Investigating human cellular proteins through a combination of highly multiplexed imaging and proteomic analyses can help characterize all human cells at the proteomic level. Discover the latest research on deep visual proteomics here.

Genetics of Autoimmunity

Genome-wide association studies have revealed pathways linked to autoimmune disorders and their pathogenesis. Discover the latest research on the Genetics of Autoimmunity here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Consumer Genomics

Consumer genomics is a rapidly advancing industry with the ability to gather large databases of genetic information of individual data. This information will allow people the ability to adapt their lifestyle and potentially modify disease trajectories in the future. Discover the latest research on consumer genomics here.

Proteogenomics

Proteogenomics is a multi-omics research field that has the aim to efficiently integrate genomics, transcriptomics and proteomics. Here is the latest research on proteogenomics.

PI3K/AKT/mTOR Pathway

The PI3K/AKT/mTOR signal transduction pathway is crucial for cell cycle, thus directly regulates cell proliferation, longevity, and cancer. Here is the latest research on this intracellular signaling pathway.

Signaling Pathways in Glioblastoma

Glioblastoma is a malignant brain tumor with mutations in various signaling pathways involved in tumorigenic processes. Developing therapeutic agents against these signaling pathways are ongoing. Discover the latest research on signaling pathways in glioblastoma.

Glioblastoma Multiforme

Glioblastoma Multiforme (GBM) is a tumor that develops from astrocytes and oligodendrocytes. Here is the latest research on mechanisms that underlie GBM and associated therapeutic approaches.

Precision Medicine

Precision medicine is a medical model that proposes the customization of healthcare, with medical decisions, treatments, practices, or products being tailored to the patient traits and specific molecular features of disease processes. In this model, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the context of a patient’s genetic content or other molecular or cellular analysis. Tools employed in precision medicine can include molecular diagnostics, imaging, and analytics

Systemic Autoimmunity

Systemic autoimmunity is a complex disease process that results from a loss of immunological tolerance, characterized by the inability of the immune system to discriminate self from non-self. Discover the latest research on Systemic Autoimmunity here.

Drug-Induced Diseases

Drug-induced diseases (DID) also called as iatrogenic diseases. Most of these DIDs are largely preventable, if strict vigilance and proper periodic clinical and diagnostic monitoring are undertaken

Kinase Inhibitors

Kinases are enzymes that transfer a phosphate group to a protein while phosphatases remove a phosphate group from protein. Kinases play a crucial role in the carcinogenesis and metastases of various types of cancer. Kinase inhibitors such as dasatinib are often used in the treatment of cancer and inflammation.

Phosphorylation

Phosphorylation is the attachment of a phosphoryl group, which is often provided by ATP, to a protein by a specific type of enzyme called kinase. Discover the latest research on phosphorylation here.

Phosphoproteomics

Phosphoproteomics refers to the identification and quantification of phosphorylated proteins in the proteome. This approach provides a high-throughput method of examining the state of intracellular phosphorylation. Here is the latest research on phosphoproteomics.

Cancer Genomics

Cancer genomics employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research here.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Biochimica Et Biophysica Acta

Phosphoproteomics of human platelets: A quest for novel activation pathways

Biochimica Et Biophysica ActaOctober 20, 2006
René P ZahediAlbert Sickmann
Journal of Molecular and Cellular Cardiology

Phosphoproteomics and molecular cardiology: techniques, applications and challenges

Journal of Molecular and Cellular CardiologyJune 14, 2012
Zeyu SunKenneth F Reardon
© 2020 Meta ULC. All rights reserved

Phosphoproteomics in drug discovery

Drug Discovery Today

Oct 22, 2013

Melody K MorrisLeonidas G Alexopoulos

PMID: 24141136

DOI: 10.1016/j.drudis.2013.10.010

Abstract

Several important aspects of the drug discovery process, including target identification, mechanism of action determination and biomarker identification as well as drug repositioning, require complete understanding of the effects of drugs on protein phosphorylation in relevant biologica...read more

Mentioned in this Paper

Anaplastic Small Cell Lymphoma
Flow Cytometry
Biochemical Pathway
Procedure to Identify Antibody
Metrorrhagia
Genome
Epidermal Growth Factor Receptor Activity
Protein Phosphorylation
Neoplasms
FRAP1 protein, human

Similar Papers Found In These Feeds

Deep Visual Proteomics: Image-Guided Cell Characterization

Investigating human cellular proteins through a combination of highly multiplexed imaging and proteomic analyses can help characterize all human cells at the proteomic level. Discover the latest research on deep visual proteomics here.

Genetics of Autoimmunity

Genome-wide association studies have revealed pathways linked to autoimmune disorders and their pathogenesis. Discover the latest research on the Genetics of Autoimmunity here.

Related Papers

Biochimica Et Biophysica Acta

Phosphoproteomics of human platelets: A quest for novel activation pathways

Biochimica Et Biophysica ActaOctober 20, 2006
René P ZahediAlbert Sickmann
Journal of Molecular and Cellular Cardiology

Phosphoproteomics and molecular cardiology: techniques, applications and challenges

Journal of Molecular and Cellular CardiologyJune 14, 2012
Zeyu SunKenneth F Reardon
Paper Details
References
  • References54
  • Citations12
12345...
  • References54
  • Citations12
12
/papers/phosphoproteomics-in-drug-discovery/24141136