Phosphoproteomics in translational research: a sarcoma perspective

Annals of Oncology : Official Journal of the European Society for Medical Oncology
J NoujaimP H Huang

Abstract

Phosphoproteomics has been extensively used as a preclinical research tool to characterize the phosphorylated components of the cancer proteome. Advances in the field have yielded insights into new drug targets, mechanisms of disease progression and drug resistance, and biomarker discovery. However, application of this technology to clinical research has been challenging because of practical issues relating to specimen integrity and tumour heterogeneity. Beyond these limitations, phosphoproteomics has the potential to play a pivotal role in translational studies and contribute to advances in different tumour groups, including rare disease sites like sarcoma. In this review, we propose that deploying phosphoproteomic technologies in translational research may facilitate the identification of better defined predictive biomarkers for patient stratification, inform drug selection in umbrella trials and identify new combinations to overcome drug resistance. We provide an overview of current phosphoproteomic technologies, such as affinity-based assays and mass spectrometry-based approaches, and discuss their advantages and limitations. We use sarcoma as an example to illustrate the current challenges in evaluating targeted kinase the...Continue Reading

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Citations

Jul 28, 2016·Drug Discovery Today·Aik-Choon TanPaul H Huang
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May 18, 2020·Signal Transduction and Targeted Therapy·Alex T J LeePaul H Huang
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Dec 4, 2021·Frontiers in Plant Science·Qingfeng ZhouHang Gao

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