Phosphopyridoxal complexes with histamine and histidine. (1) The kinetics of complex formation between pyridoxal 5'-phosphate and histamine.

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D KierskaC Maślinski

Abstract

Amines and amino acids are able to form cyclic compounds with pyridoxal 5'-phosphate (PLP). The quantitative relationship between histamine and PLP in the cyclization reaction were examined. It was found that one mole of amine reacts with one mole of coenzyme. The velocity of complex formation increased with an excess of either histamine or PLP, without any change in molar ratios. The formation of cyclic compound was confirmed by the use of isotopic method. The separation of cyclic compound from histamine, but not from PLP, was achieved by paper chromatography.

References

Jul 1, 1972·Archives of Biochemistry and Biophysics·J T NearyW F Diven
Sep 1, 1967·Acta Physiologica Scandinavica·O V Sjaastad
Nov 1, 1948·Journal of the American Chemical Society·D HEYL, E LUZ
Apr 1, 1948·Journal of the American Chemical Society·D HEYL, E LUZ

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