PhosphoregDB: the tissue and sub-cellular distribution of mammalian protein kinases and phosphatases

BMC Bioinformatics
Alistair R R ForrestSean M Grimmond

Abstract

Protein kinases and protein phosphatases are the fundamental components of phosphorylation dependent protein regulatory systems. We have created a database for the protein kinase-like and phosphatase-like loci of mouse http://phosphoreg.imb.uq.edu.au that integrates protein sequence, interaction, classification and pathway information with the results of a systematic screen of their sub-cellular localization and tissue specific expression data mined from the GNF tissue atlas of mouse. The database lets users query where a specific kinase or phosphatase is expressed at both the tissue and sub-cellular levels. Similarly the interface allows the user to query by tissue, pathway or sub-cellular localization, to reveal which components are co-expressed or co-localized. A review of their expression reveals 30% of these components are detected in all tissues tested while 70% show some level of tissue restriction. Hierarchical clustering of the expression data reveals that expression of these genes can be used to separate the samples into tissues of related lineage, including 3 larger clusters of nervous tissue, developing embryo and cells of the immune system. By overlaying the expression, sub-cellular localization and classification ...Continue Reading

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Methods Mentioned

BETA
PCR
electrophoresis
FCS
transfection
GTPase
PCRs

Software Mentioned

Proteome Analyst
GeneSpring
DBSubLoc
SubLocV1
InterProScan
NetNES
SubLoc
PhosphoregDB
TMHMM
Excel

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