Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or β1-Adrenergic Stimulation

Circulation. Heart Failure
Carl W TongRichard L Moss

Abstract

Mammalian hearts exhibit positive inotropic responses to β-adrenergic stimulation as a consequence of protein kinase A-mediated phosphorylation or as a result of increased beat frequency (the Bowditch effect). Several membrane and myofibrillar proteins are phosphorylated under these conditions, but the relative contributions of these to increased contractility are not known. Phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) by protein kinase A accelerates the kinetics of force development in permeabilized heart muscle, but its role in vivo is unknown. Such understanding is important because adrenergic responsiveness of the heart and the Bowditch effect are both depressed in heart failure. The roles of cMyBP-C phosphorylation were studied using mice in which either WT or nonphosphorylatable forms of cMyBP-C [ser273ala, ser282ala, ser302ala: cMyBP-C(t3SA)] were expressed at similar levels on a cMyBP-C null background. Force and [Ca(2+)]in measurements in isolated papillary muscles showed that the increased force and twitch kinetics because increased pacing or β1-adrenergic stimulation were nearly absent in cMyBP-C(t3SA) myocardium, even though [Ca(2+)]in transients under each condition were similar to WT. Biochemical ...Continue Reading

References

Jul 1, 1995·Journal of Molecular and Cellular Cardiology·J WattanapermpoolR J Solaro
Jan 1, 1996·Basic Research in Cardiology·G HasenfussH Just
Feb 14, 1997·Journal of Molecular Biology·P VibertW Lehman
Jan 31, 1998·Science·P De Koninck, H Schulman
Jan 12, 2001·Journal of the American College of Cardiology·S F NaguehD S Khoury
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y WuM E Anderson
Jan 24, 2002·Nature·Donald M Bers
May 29, 2004·Circulation Research·Emily FlashmanHugh Watkins
Jun 15, 2004·The Journal of Physiology·Carl W TongMariappan Muthuchamy
Oct 15, 2005·Circulation Research·Sakthivel SadayappanJeffrey Robbins
Nov 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Neil M KadJosh E Baker
Jan 12, 2007·Echocardiography·Jeffrey N RottmanMichael Brown
Feb 25, 2009·Circulation·Sakthivel SadayappanJeffrey Robbins
Mar 9, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Jeong-Sook SeoJae-Kwan Song
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alexander KushnirAndrew R Marks
Sep 21, 2010·Journal of Molecular and Cellular Cardiology·O'Neal CopelandSteven B Marston
Dec 15, 2010·The Journal of Biological Chemistry·Friederike CuelloMetin Avkiran
Jan 20, 2011·Circulation. Cardiovascular Imaging·Robert L Hamlin, Ruth A Altschuld
May 21, 2011·Circulation Research·Sakthivel SadayappanJeffrey Robbins
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Brett A ColsonDavid D Thomas
Apr 27, 2013·Journal of Molecular and Cellular Cardiology·Viola KooijJennifer E Van Eyk
Feb 18, 2014·Journal of Molecular and Cellular Cardiology·Elizabeth D Luczak, Mark E Anderson

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Citations

Feb 26, 2016·Frontiers in Physiology·Ranganath MamidiJulian E Stelzer
Feb 26, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michael J PrevisRoger Craig
Mar 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Richard L Moss
Jul 15, 2016·Nature Reviews. Cardiology·Julian O M OrmerodMark V Sherrid
May 21, 2015·Circulation. Heart Failure·Martin M LeWinter, Bradley M Palmer
Oct 20, 2015·Circulation. Heart Failure·Robrecht ThoonenRobert M Blanton
Jul 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Saraswathi PonnamThomas Kampourakis
Dec 3, 2016·Journal of Applied Physiology·Kenneth S GreshamJulian E Stelzer
Jun 20, 2020·The Journal of Biological Chemistry·Mohit KumarSakthivel Sadayappan
Dec 24, 2018·The Journal of General Physiology·Jasmine GilesRichard L Moss
Mar 28, 2017·Science Advances·Ranganath MamidiJulian E Stelzer
May 31, 2019·Proceedings of the National Academy of Sciences of the United States of America·James W McNamaraSakthivel Sadayappan
Aug 30, 2019·Journal of Cardiovascular Pharmacology·Robert M Blanton
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Robert W KenslerRichard L Moss
Jan 20, 2021·Circulation. Heart Failure·Daniel A RichardsRobert M Blanton
Feb 11, 2021·The Journal of General Physiology·Jasmine GilesRichard L Moss
Mar 2, 2021·The Journal of General Physiology·Laurin M HanftKerry S McDonald
Mar 20, 2021·The Journal of General Physiology·Christopher Solís, R John Solaro
Sep 26, 2020·Cellular Signalling·Alice MainGeorge S Baillie
Oct 13, 2015·Journal of Molecular and Cellular Cardiology·Sabine J van DijkSamantha P Harris

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