Phosphorescent Starburst Pt(II) Porphyrins as Bifunctional Therapeutic Agents for Tumor Hypoxia Imaging and Photodynamic Therapy

ACS Applied Materials & Interfaces
Zhuang LvQiang Zhao

Abstract

It is very meaningful to develop bifunctional therapeutic agents which can monitor the tumor hypoxia in real time as well as maintain good photodynamic therapy (PDT) effect under hypoxia. To achieve it, herein, a series of hydrophilic phosphorescent starburst Pt(II) porphyrins as bifunctional therapeutic agents for simultaneous tumor hypoxia imaging and highly efficient PDT have been rationally designed and synthesized. They have been obtained by using Pt(II) porphyrins as the functional core and cationic oligofluorenes as the arms. Such a three-dimensional structural feature ensures their hydrophilicity, ultrasensitive oxygen-sensing performance, and high 1O2 quantum yields. Furthermore, the O2-sensitive phosphorescence lifetimes of starburst Pt(II) porphyrins are beneficial to eliminate the interference from background fluorescence remarkably and enhance the signal-to-noise ratio of hypoxia imaging by using phosphorescence lifetime imaging microscopy. Their PDT effects were also evaluated both in vitro (under both hypoxia and normoxia) and in vivo. As a result, tumor hypoxia can be significantly differentiated and tumor growth can be inhibited effectively, while the systemic toxicity is not observed. All of these results demo...Continue Reading

References

Nov 1, 1992·The Journal of Surgical Research·V H FingarB W Henderson
Jan 1, 1992·Photochemistry and Photobiology·B W Henderson, T J Dougherty
Jan 1, 1987·Cancer Metastasis Reviews·J E Moulder, S Rockwell
Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Miguel López-Lázaro
Jun 24, 2006·Nature Reviews. Cancer·Ana P CastanoMichael R Hamblin
Apr 11, 2008·Physics in Medicine and Biology·Brian C Wilson, Michael S Patterson
Jul 23, 2008·Technology in Cancer Research & Treatment·Zheng HuangYang K Chen
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Oct 12, 2012·Angewandte Chemie·Samantha L H Higgins, Karen J Brewer
May 23, 2014·Analytical Chemistry·Emmanuel RoussakisSergei A Vinogradov
Aug 12, 2014·Nature Communications·Jiechao GeXiaodong Han
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 3, 2015·Coordination Chemistry Reviews·Jessica D Knoll, Claudia Turro
Aug 6, 2016·Journal of the American Chemical Society·Jung Seung NamTae-Hyuk Kwon
Nov 18, 2016·Laser Therapy·Hiromu Ito, Hirofumi Matsui
May 1, 2015·Chemical Science·Cristina MariGilles Gasser

❮ Previous
Next ❯

Citations

May 9, 2019·Advanced Healthcare Materials·Minhuan LanPengfei Wang
Nov 2, 2019·Pharmaceuticals·Ludivine LarueCéline Frochot
Nov 27, 2020·Advanced Healthcare Materials·Miffy Hok Yan ChengGang Zheng
Mar 30, 2021·Materials Horizons·Zhen YangXiaoyuan Chen
May 22, 2021·Journal of Medicinal Chemistry·Carime V RodriguesAna de Bettencourt-Dias
Aug 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fan WuAo Li
Sep 17, 2019·ACS Applied Materials & Interfaces·Dawei JiangWeian Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.