Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae

Yeast
A T CarterMichael Schweizer

Abstract

Saccharomyces cerevisiae contains at least four PRS genes, all of which have been cloned and sequenced. Each of the four derived amino acid sequences have more than 60% similarity to the corresponding polypeptides of man, rat, Escherichia coli and Salmonella typhimurium. The PRS1 gene maps on chromosome XI, PRS2 on chromosome V, PRS3 on chromosome VIII and PRS4 on chromosome II. One member of this gene family, PRS1, contains a region of non-homology (NHR) shown by cDNA cloning and sequencing not to be an intron. The results presented here suggest that the presence of this NHR is not detrimental to the function of the gene. To date the possibility of protein splicing can be neither proven nor disputed.

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Citations

Oct 25, 2008·The Journal of Biological Chemistry·Robert L Switzer
Dec 30, 2016·Microbiology and Molecular Biology Reviews : MMBR·Bjarne Hove-JensenMartin Willemoës
Dec 24, 1997·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·T Payne, R Calderone
Sep 17, 2009·Biochemical Society Transactions·Anna KleineidamMichael Schweizer
Jul 27, 1999·FEMS Microbiology Letters·K Larkin, M Schweizer
Oct 29, 2020·G3 : Genes - Genomes - Genetics·Michael C AyersJennifer E G Gallagher

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