Phosphorus-Based Probes as Molecular Tools for Proteome Studies: Recent Advances in Probe Development and Applications

Journal of Medicinal Chemistry
Łukasz Joachimiak, Katarzyna M Błażewska

Abstract

Studies on the human proteome have engaged diverse techniques; however, none of them represent a predominant approach. Chemical biology has made a major contribution to our understanding of human biology, stimulating the generation of biological hypotheses. Tools such as functional probes have advanced studies on biological mechanisms and helped in elucidating off-target reactivity and potential toxicities of drugs and drug candidates. Here, we accentuate the recent developments in the design and applications of phosph(on)ate-containing probes. Phosphate esters and anhydrides are present in a number of vital cell constituents, and their significance can be reflected by a number of biological processes that involve phosphorus-bearing molecules. We discuss the use of phosph(on)ate-derived probes for (1) the identification of phosphate-requiring enzymes, their substrates, interacting partners; (2) developing screening assays; and (3) their potential as diagnostics. Limitations that as yet need to be overcome and possible measures to be undertaken will also be addressed.

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Citations

Aug 15, 2018·Chemical Communications : Chem Comm·Przemyslaw WanatJoanna Kowalska
Jan 7, 2020·Chemical Communications : Chem Comm·Yingcong OuQian Chen
Dec 14, 2019·Chembiochem : a European Journal of Chemical Biology·Samuel E Dalton, Sebastien Campos
Jul 11, 2020·Beilstein Journal of Organic Chemistry·Katarzyna JustynaKatarzyna M Błażewska

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