Phosphorus-containing dendrimers against α-synuclein fibril formation

International Journal of Biological Macromolecules
Katarzyna MilowskaJean-Pierre Majoral

Abstract

The aim of this work was to study the effect of phosphorus-containing dendrimers (generations G3 and G4) on the fibrillation of α-synuclein (ASN). The inhibition of fibril formation (filamentous and aggregates) is a potential therapeutic strategy for neurodegenerative disorders such as Parkinson's and other motor disorder neurodegenerative diseases. The interaction between phosphorus-containing dendrimers and ASN was studied by fluorescence spectroscopy. The decrease in the fluorescence intensity of intrisinic tyrosine was the most marked change in the fluorescence intensity observed upon addition of dendrimers. Furthermore, the effect of dendrimers on ASN fibril formation was studied using circular dichroism (CD) spectroscopy and CD studies were complemented by fluorescence assays using the dye thioflavin T (ThT). The results showed that phosphorus-containing dendrimers G3 and G4 inhibited fibril formation, when they were used in the ASN/dendrimer ratios 1:0.1 and 1:0.5. However, the higher concentrations of dendrimers did not show this effect.

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Citations

Aug 12, 2014·International Journal of Pharmaceutics·Katarzyna MilowskaMaria Bryszewska
Mar 13, 2014·International Journal of Nanomedicine·Masihuz ZamanRizwan Hasan Khan
Oct 3, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joanna LazniewskaBarbara Klajnert-Maculewicz
Nov 26, 2015·International Journal of Biological Macromolecules·Olga NowackaMaria Bryszewska
Jul 31, 2013·Cellular & Molecular Biology Letters·Joanna LazniewskaTeresa Gabryelak
Mar 5, 2015·International Journal of Pharmaceutics·Katarzyna MilowskaMaria Bryszewska
Feb 9, 2017·Colloids and Surfaces. B, Biointerfaces·Dzmitry ShcharbinMaria Bryszewska
Jul 27, 2017·Chemical Communications : Chem Comm·Anne-Marie Caminade
Nov 9, 2012·Chemistry : a European Journal·Josefina JiménezLuis Oriol
Jun 1, 2013·Advanced Materials·Min ZhangChen Wang
Aug 4, 2019·Biomolecules·Anna JanaszewskaBarbara Klajnert-Maculewicz
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariapina D'OnofrioMichael Assfalg
Aug 1, 2013·Molecular Pharmaceutics·Joanna LazniewskaTeresa Gabryelak
Feb 6, 2013·Molecular Pharmaceutics·Katarzyna MilowskaTeresa Gabryelak
Aug 21, 2021·Scientific Reports·Katarzyna MilowskaMaria Bryszewska
Dec 18, 2015··Francisco Javier de la MataKatarzyna Milowska

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