Phosphorus metabolites of liver from mice infected with Hymenolepis microstoma

International Journal for Parasitology
B J BlackburnM Novak

Abstract

31P NMR in vivo spectra of mouse livers infected with Hymenolepis microstoma for 130 or 265 days showed modifications in phosphorus-containing metabolite ratios when compared to those of normal liver. After 130 days of infection the metabolite ratio of inorganic phosphate (Pi)/beta ATP significantly increased whereas that of phosphocreatine (PCr)/beta ATP significantly decreased. In older, 265 day infections, the increase in Pi/beta ATP and decrease in PCr/beta ATP persisted. Changes in the group infected for 130 days were accompanied by lowered pH. Analysis of liver extracts from mice with 130-day-old. H. microstoma revealed significantly lower concentrations of Pi, ATP and ADP compounds. In those from mice infected for 265 days the concentration of Pi remained low whereas concentrations of ATP and ADP increased to levels in between those of controls and the 130-day-old infection. In addition, levels of phosphorylethanolamine (PE) and of an unknown metabolite significantly increased in this latter group. Worm extracts contained high levels of glycerophosphorylcholine (GPC), Pi, fructose 1,6-diphosphate (FDP), PE, diphosphodiesters (DPDE), phosphorylcholine (PC) and glycerolphosphorylethanolamine (GPE) in order of declining con...Continue Reading

References

Aug 1, 1990·Molecular and Biochemical Parasitology·R GroteW J O'Sullivan
Aug 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F A HofferT Fenton
Aug 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R G SteenJ P Wehrle
Jul 1, 1986·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·S R Williams, D G Gadian
Jul 1, 1986·Archives of Biochemistry and Biophysics·S P RohrerT Nowak
Jan 2, 1987·Molecular and Biochemical Parasitology·S N ThompsonR W Lee
Jan 23, 1986·Biochimica Et Biophysica Acta·C R MalloyG K Radda
Sep 1, 1982·Molecular and Biochemical Parasitology·A G TielensS G van den Bergh
Dec 30, 1982·Biochimica Et Biophysica Acta·T E MansourG C Roberts

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