Phosphorylated AKT1 is associated with poor prognosis in esophageal squamous cell carcinoma

Journal of Experimental & Clinical Cancer Research : CR
Zheng-fei ZhuKuai-le Zhao

Abstract

The epidermal growth factor receptor (EGFR) signaling pathway is important in regulating biological behaviors in many malignancies. We explored whether expression and activation of EGFR and several components on its downstream pathways have prognostic significance in patients with esophageal squamous cell carcinoma (ESCC). Expression of EGFR, phosphorylated (p)-EGFR, AKT1, p-AKT1, AKT2, p-AKT2, ERK1, ERK2, p-ERK1/2, STAT3, and p-STAT3 was assessed by immunohistochemical analysis of tissue microarrays for 275 ESCC patients who had undergone complete three-field lymphadenectomy. Spearman rank correlation tests were used to determine the relationships among protein expression, and Cox regression analyses were performed to determine the prognostic factors on overall survival (OS). p-EGFR expression was correlated statistically with all of the other phosphorylated markers. Gender, N stage, and p-AKT1 expression were found to be independent prognostic factors for OS. Increased expression of p-AKT1 was associated with decreased patient survival. EGFR and p-EGFR expression was not significantly associated with patient survival. Activation of AKT1 was associated with poor prognosis in ESCC.

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Citations

Jun 18, 2017·Life Sciences·Daniela Recabarren, Marcelo Alarcón
Nov 6, 2017·Pathology Oncology Research : POR·Laszló ZoltanSzabolcs Bellyei
Jun 30, 2019·Biomolecules·Nand Kishor RoyAjaikumar B Kunnumakkara
Oct 7, 2015·Journal of Experimental & Clinical Cancer Research : CR·Bo WuZhi-Nan Chen

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Methods Mentioned

BETA
biopsy

Software Mentioned

Statistical Package for the Social Sciences software ( SPSS

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