Phosphorylated chitin increased bone formation when implanted into rat calvaria with the Ti-device.

Bio-medical Materials and Engineering
Qin SongYoshinori Kuboki

Abstract

Previously we found that a group of phosphorylated proteins (SIBLINGs) in bone binds with the Ti-device, and increases the early bone formation around the Ti-implants remarkably. From these results, we explained the biochemical mechanism of a strong bond between living bone and Ti, which was discovered by Brånemark and colleagues. For the clinical application of our findings, we need a large amount of these proteins or their substitutes. We aimed to create a new molecule that equips with essential functions of SIBLINGs, Ti-binding, and bone enhancement around the Ti implant. We chemically phosphorylated chitin and obtained a soluble form of phosphorylated chitin (P-chitin). In this solution, we immersed the Ti-devices of web-form (TW) which we previously developed and obtained the P-chitin coated TWs. Then we tested the P-chitin coated TWs for their calcification ability in vitro, and bone enhancing ability in vivo, by implanting them into rat calvaria. We compared the P-chitin coated TW and the non-coated TW in regard to their calcification and bone enhancing abilities. Ti-devices coated with phosphorylated-chitin induced a ten times higher calcification in vitro at 20 days, and four times more elevated amount of bone formatio...Continue Reading

References

Sep 25, 1957·The Journal of Biophysical and Biochemical Cytology·D CARLSTROM
May 5, 2006·Clinical Oral Implants Research·Ge ZhaoBarbara D Boyan
Apr 2, 2009·Biomacromolecules·Pawel SikorskiMasahisa Wada
Oct 2, 2012·Bio-medical Materials and Engineering·Yoshinori KubokiRachel Sammons
Jun 12, 2013·The International Journal of Oral & Maxillofacial Implants·Marwa MadiShohei Kasugai

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