Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain

Neuroreport
Xu LiJin-Jing Pei

Abstract

Eukaryotic translation factor 4E (eIF4E) plays a key role in regulating protein translation. It was thought that in order to maintain neuronal functions, tau protein is continuously generated to compensate those being hyperphosphorylated and compromised in its ability to promote and maintain microtubule assembly in Alzheimer's disease. If eIF4E is involved in tau mRNA translation, level of eIF4E phosphorylation should be changed. In the current study, we found a dramatic increase of phosphorylated eIF4E in Alzheimer's disease, especially in those cases with late stages of neurofibrillary changes. Level of eIF4E phosphorylation is significantly correlated with total- and Alzheimer hyperphosphorylated taus. These data suggest that the increase of eIF4E phosphorylation is involved in formation of Alzheimer neurofibrillary changes.

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Jun 16, 1995·The Journal of Biological Chemistry·B JoshiR E Rhoads
Jan 1, 1997·Journal of Neuropathology and Experimental Neurology·J J PeiI Grundke-Iqbal
Jan 24, 1997·Science·M W Hentze
Sep 28, 1999·Journal of Neuropathology and Experimental Neurology·J J PeiR F Cowburn
Oct 6, 2000·Journal of Neuroscience Research·M López SalonJ M Pasquini
Mar 8, 2003·Acta Neuropathologica·Jin-Jing PeiKhalid Iqbal

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Citations

Oct 12, 2007·Molecular Biology of the Cell·Michelle L SteinhilbMel B Feany
Nov 21, 2013·Acta Neuropathologica Communications·Sharon C YatesZsuzsanna Nagy
Dec 21, 2005·FEBS Letters·Jin-Jing PeiBengt Winblad
May 1, 2008·Expert Opinion on Medical Diagnostics·Steven Pelech
Feb 24, 2009·Parkinsonism & Related Disorders·Qin ShenLu Lu
Jul 16, 2009·Journal of Cellular and Molecular Medicine·Milena MorelGuylène Page
Feb 13, 2009·Journal of Cellular and Molecular Medicine·Jin-Jing Pei, Jacques Hugon
May 22, 2013·Neurotoxicology·Pradip K KamatChandishwar Nath
Oct 30, 2015·Brain Pathology·Karina Hernández-OrtegaIsidre Ferrer
Feb 17, 2017·Biochemistry·Mia K MihailovicLydia M Contreras
May 29, 2018·Reviews in the Neurosciences·Ghazaleh KheiriNima Rezaei
Aug 15, 2014·International Journal of Molecular Medicine·Julie DaviesEmmanouil Karteris
Jul 30, 2020·International Journal of Molecular Sciences·Tiffany J Rios-FullerRobert J Schneider
Sep 10, 2020·Frontiers in Neuroscience·Nicholas G Norwitz, Henry Querfurth
Jan 27, 2017·Translational Neuroscience·Xu WangXiao-Ming Jiang

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