Phosphorylated extracellular signal-regulated kinases are significantly increased in malignant mesothelioma

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Merivane de MeloJean-Claude Pache

Abstract

Tumorigenesis is associated with the activation of mitogenic signal transduction pathways. The expression of activated extracellular signal-regulated kinase (p-ERK) may play an important role in cell proliferation of malignant mesothelioma (MM). We compare the expression of p-ERK in 50 biopsy specimens of MM, non-small-cell lung cancer (NSCLC), and normal lung tissue. We hypothesized that phosphorylated extracellular signal-regulated kinase is increased in MM. We stained the sections by immunohistochemistry for activated ERK-1 and -2 and performed the quantification of the stained nuclei. Quantitative analysis of p-ERK showed a high percentage score in MM (30.3 +/- 4.6%) as compared with NSCLC (12.2 +/- 2.1%) (p<0.01) and control lung tissue (6.4 +/- 1.3%) (p=0.0002). Furthermore, p-ERK was found significantly higher in poorly differentiated NSCLC (17.7 +/- 3.1%) as compared with well-differentiated NSCLC (5.4 +/- 1.2%) (p<0.01). Our data show that the nuclear quantification of p-ERK is significantly increased in MM and poorly differentiated NSCLC in comparison to well-differentiated NSCLC and normal lung tissue. These results corroborate previous experimental studies that suggest a critical role of p-ERK in cell proliferation ...Continue Reading

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Citations

Jan 14, 2010·American Journal of Respiratory Cell and Molecular Biology·Nicholas H HeintzBrooke T Mossman
Apr 2, 2011·American Journal of Respiratory Cell and Molecular Biology·Arti ShuklaBrooke T Mossman
Mar 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arti ShuklaBrooke T Mossman
Mar 1, 2012·Archives of Pathology & Laboratory Medicine·Didier JeanMarie-Claude Jaurand
Aug 27, 2015·Expert Review of Respiratory Medicine·Angela BononiMichele Carbone
Jan 14, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jun ZhongMichael Roth
Oct 10, 2009·The American Journal of Pathology·Arti ShuklaBrooke T Mossman
Jun 29, 2011·International Journal of Cancer. Journal International Du Cancer·Arti ShuklaBrooke T Mossman
Feb 5, 2014·Biochimica Et Biophysica Acta·Leonardo Vinícius Monteiro de AssisMauro César Isoldi
Apr 4, 2009·Cell Death and Differentiation·J DaubriacM-C Jaurand
Sep 12, 2014·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi
May 15, 2012·International Journal of Oncology·Seigo MiyoshiJitsuo Higaki

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Methods Mentioned

BETA
biopsies

Software Mentioned

GraphPad
GraphPrism

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