Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically?

Oncology Letters
Xianwang WangLei Liu

Abstract

Forkhead box class O 3a (FOXO3a) is a transcription factor that has emerged as being a tumor suppressor and longevity factor. The precise regulation of FOXO3a transactivation of target genes is achieved via post-translational modifications (PTMs) and specific protein-protein interactions. The multiple types of PTMs that FOXO3a undergoes, including phosphorylation, acetylation, methylation and ubiquitination, serve important roles in directing its subcellular localization and transcription activity, which are central to the integration of insulin/growth factor signaling and oxidative/nutrient stress signaling. The present review summarizes the modifications of FOXO3a that occur via phosphorylation and acetylation. In addition, the synergistic effect of multiple phosphorylations on FOXO3a and the crosstalk between phosphorylation and acetylation in the regulation of FOXO3a are discussed. These discussions may highlight potential strategies for the prevention of cancer and aging.

References

Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
May 6, 2004·The Journal of Biological Chemistry·Armando van der HorstBoudewijn M T Burgering
Jun 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki DaitokuAkiyoshi Fukamizu
Nov 13, 2004·The EMBO Journal·Marieke A G EssersBoudewijn M T Burgering
Feb 5, 2005·Trends in Biochemical Sciences·Lars P van der Heide, Marten P Smidt
Aug 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hitomi MatsuzakiAkiyoshi Fukamizu
Jan 22, 2008·Nature Cell Biology·Jer-Yen YangMien-Chie Hung
Mar 22, 2008·Science·Zengqiang YuanAzad Bonni
Apr 9, 2008·Oncogene·D R Calnan, A Brunet
Sep 8, 2009·BMC Evolutionary Biology·Minghui WangYuchun Pan
Dec 24, 2009·The Journal of Biological Chemistry·Wenzhi BiZengqiang Yuan
Dec 15, 2010·Biochimica Et Biophysica Acta·Tomas Obsil, Veronika Obsilova
Mar 8, 2011·Journal of Cell Science·Takashi Nakagawa, Leonard Guarente
Mar 11, 2011·American Journal of Physiology. Cell Physiology·Sarah M SenfAndrew R Judge
Mar 15, 2011·Biochimica Et Biophysica Acta·Hiroaki DaitokuAkiyoshi Fukamizu
Mar 30, 2011·Current Drug Targets·Marco Boccitto, Robert G Kalb
May 5, 2011·Biochimica Et Biophysica Acta·David E A Kloet, Boudewijn M T Burgering
May 31, 2011·Biochimica Et Biophysica Acta·Melissa DobsonGuri Tzivion
Jun 15, 2011·Journal of Molecular Cell Biology·Ying ZhaoWei-Guo Zhu
Nov 19, 2011·American Journal of Physiology. Cell Physiology·Enrico BertaggiaMarco Sandri
Dec 1, 2011·The Journal of Biological Chemistry·Ka-Kei HoEric W-F Lam
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Feng WangMitsuhiko Ikura
Jul 17, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Irina TikhanovichSteven A Weinman
Nov 7, 2014·Journal of Neuro-oncology·Yuewen ChaoXiuping Zhou
Dec 17, 2014·Apoptosis : an International Journal on Programmed Cell Death·Jiao WangYangfu Jiang
Feb 24, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deveroux FergusonEric J Nestler

❮ Previous
Next ❯

Citations

Nov 23, 2019·Cancer Communications·Dan DingJian-Xun Wang
Oct 28, 2019·The Journal of Clinical Investigation·Samreen FatimaGobardhan Das
May 15, 2020·Journal of Cellular and Molecular Medicine·Naeun LeeChul-Ho Jeong
Jun 17, 2020·Expert Opinion on Drug Discovery·Dasol KimHo Jeong Kwon
Sep 1, 2020·Molecular Neurobiology·Asmaa AbdullahSuzana Makpol
Jul 27, 2018·Molecular Cancer·Ying LiuJianxun Wang
Jun 14, 2020·Signal Transduction and Targeted Therapy·Ling ChenYongguang Tao
Aug 23, 2018·Frontiers in Physiology·Rebecca M Parodi-RullánSabzali Javadov
Sep 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng XuBaohong Zhao
Dec 26, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ban WangHaichun Ma
Mar 15, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Raúl VivarGuillermo Diaz-Araya
Jan 10, 2021·International Journal of Environmental Research and Public Health·Marcus M LawrenceR Andrew Shanely
May 25, 2020·Ageing Research Reviews·Vittoria CenniGiovanna Lattanzi
Jan 26, 2018·Seminars in Cancer Biology·Matías González-QuirozClaudio Hetz
May 22, 2021·Cell Communication and Signaling : CCS·Mehrshad Sadria, Anita T Layton
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sang Hee ParkJae Youl Cho
Jun 3, 2021·Neurochemical Research·Tarapati RanaSimona Bungau
Nov 10, 2021·International Journal of Cancer. Journal International Du Cancer·Sharareh BordbariJadwiga Jablonska

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
nuclear translocation
transfection
ubiquitination

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.