PMID: 8592157Feb 1, 1996Paper

Phosphorylation and activation of tryptophan hydroxylase by exogenous protein kinase A

Journal of Neurochemistry
P A JohansenD M Kuhn

Abstract

The catalytic subunit of protein kinase A increases brain tryptophan hydroxylase activity. The activation is manifested as an increase in Vmax without alterations in the Km for either tetrahydrobiopterin or tryptophan. The activation of tryptophan hydroxylase by protein kinase A is dependent on ATP and an intact kinase and is inhibited specifically by protein kinase A inhibitors. Protein kinase A also catalyzes the phosphorylation of tryptophan hydroxylase. The extent to which tryptophan hydroxylase is phosphorylated by protein kinase A is dependent on the amount of kinase used and is closely related to the degree to which the hydroxylase is activated. These results suggest that a direct relationship exists between phosphorylation and activation of tryptophan hydroxylase by protein kinase A.

Citations

Oct 14, 2004·Invertebrate Neuroscience : in·Chandra M Coleman, Wendi S Neckameyer
Jul 21, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gabriel Manjarrez-GutierrezJorge Hernandez-Rodriguez
Apr 12, 2005·Archives of Insect Biochemistry and Physiology·Chandra M Coleman, Wendi S Neckameyer
Feb 18, 2014·British Journal of Pharmacology·Stephen P H AlexanderUNKNOWN CGTP Collaborators
Jan 16, 2015·Molecular Neurobiology·Ana Catarina MenezesAndreia Ascenso
Oct 15, 1998·Journal of Molecular Neuroscience : MN·S M Mockus, K E Vrana
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Francine CôtéGuilan Vodjdani
May 12, 2007·Journal of Neuroscience Research·Roberto W Invernizzi
Jul 24, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gabriel Manjarrez-GutiérrezJorge Hernández-Rodríguez
Mar 22, 2002·Frontiers in Neuroendocrinology·Cynthia L BetheaJohn M Streicher
Jul 1, 1998·Brain Research. Molecular Brain Research·N Teerawatanasuk, L G Carr
Oct 18, 2003·Biochemical Pharmacology·Diego J Walther, Michael Bader

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