PMID: 7536880Jan 1, 1995Paper

Phosphorylation and adrenergic chronotropism and inotropism in guinea pig cardiac muscles

Life Sciences
H Gotoh

Abstract

A question whether phosphorylation is involved in adrenergic effects on cardiac tissues has long been a matter of dispute. We examined whether phosphorylation is involved in adrenergic chronotropism and inotropism in excised cardiac muscles from guinea pigs. KT5720, a specific inhibitor of A-kinase, abolished the late phase of adrenergic chronotropism. Okadaic acid, an inhibitor of phosphoprotein phosphatases, and IBMX (1-methyl, 3-isobutylxanthine), a phosphodiesterase inhibitor, potentiated the chronotropism. The adrenergic inotropism was influenced neither by KT5720, okadaic acid, nor by IBMX. The specific beta 1 -adrenergic agonist, denopamine, showed actions similar to adrenaline and susceptibility to the inhibitors. Adrenaline of 10 microM showed a chronotropic time course consisting of early and late components. We concluded that only the late component results from phosphorylation, and its early one and the inotropism is entirely independent of phosphorylation.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·H C VenterN O Kaplan
Apr 1, 1986·Pflügers Archiv : European journal of physiology·G CallewaertE Carmeliet
Aug 1, 1988·Pflügers Archiv : European journal of physiology·J HeschelerW Trautwein
Jan 30, 1987·Biochemical and Biophysical Research Communications·H KaseM Kaneko
Apr 1, 1973·Circulation Research·B E Sobel, S E Mayer
Oct 1, 1980·Pflügers Archiv : European journal of physiology·A NomaH Irisawa

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Citations

May 18, 2011·Physiological Research·I Falcao-PiresA F Leite-Moreira

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