Phosphorylation Impacts Cu(II) Binding by ATCUN Motifs.

Inorganic Chemistry
Tomasz Frączyk

Abstract

ATCUN (amino terminal Cu(II) and Ni(II) binding) motifs chelate Cu(II) ions strongly. However, the impact of the phosphorylation of neighboring residues on such complexation has not been elucidated. The copper(II) dissociation constants of original and phosphorylated peptides from human histatin-1 and human serum albumin were compared using spectroscopic methods. Phosphorylation markedly weakened Cu(II) binding. Thus, these results indicate that phosphorylation may be a vital mechanism governing metal ion binding.

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Dec 24, 2019·Chemistry & Biodiversity·Tomasz FrączykWojciech Bal
Apr 2, 2020·Scientific Reports·Tiina KirsipuuPeep Palumaa
Feb 23, 2021·Chemistry & Biodiversity·Tomasz Frączyk

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