PMID: 9429159Jan 16, 1998Paper

Phosphorylation of a high molecular weight (approximately 600 kDa) protein regulates catch in invertebrate smooth muscle

Journal of Muscle Research and Cell Motility
Marion J SiegmanT M Butler

Abstract

A unique property of smooth muscle is its ability to maintain force with a very low expenditure of energy. This characteristic is highly expressed in molluscan smooth muscles, such as the anterior byssus retractor muscle (ABRM) of Mytilus edulis, during a contractile state called 'catch'. Catch occurs following the initial activation of the muscle, and is characterized by prolonged force maintenance in the face of a low [Ca2+]i, high instantaneous stiffness, a very slow cross-bridge cycling rate, and low ATP usage. In the intact muscle, rapid relaxation (release of catch) is initiated by serotonin, and mediated by an increase in cAMP and activation of protein kinase A. We sought to determine which proteins undergo a change in phosphorylation on a time-course that corresponds to the release of catch in permeabilized ABRM. Only one protein consistently satisfied this criterion. This protein, having a molecular weight of approximately 600 kDa and a molar concentration about 30 times lower than the myosin heavy chain, showed an increase in phosphorylation during the release of catch. Under the mechanical conditions studied (rest, activation, catch, and release of catch), changes in phosphorylation of all other proteins, including m...Continue Reading

Citations

Jun 10, 2005·Journal of Neurophysiology·Yuriy Zhurov, Vladimir Brezina
Jul 19, 2008·Journal of Muscle Research and Cell Motility·Yoshiko TajimaAkihiko Ito
May 15, 2009·The Journal of Biological Chemistry·Daisuke FunabaraShugo Watabe
Feb 4, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Elena Fabbri, Antonio Capuzzo
Feb 3, 2011·Journal of Muscle Research and Cell Motility·Thomas M Butler, Marion J Siegman
Oct 19, 2004·Pflügers Archiv : European journal of physiology·Stefan GallerHerbert Grassberger
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J SiegmanT M Butler
Feb 3, 2006·Journal of Muscle Research and Cell Motility·Daisuke FunabaraShugo Watabe
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Thomas M Butler, Marion J Siegman
Jun 23, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Stanislava V AvrovaStefan Galler
Mar 29, 2013·Journal of Muscle Research and Cell Motility·Akira YamadaKazuhiro Oiwa
Jul 1, 2005·Physiological Reviews·Scott L Hooper, Jeffrey B Thuma
Nov 29, 2008·Journal of Muscle Research and Cell Motility·Stefan Galler
Aug 30, 2012·Acta Biologica Hungarica·V DyachukElena E Voronezhskaya
Oct 18, 2020·International Journal of Molecular Sciences·Haruo SugiMasamichi Moriya
Oct 20, 2019·Biochemical and Biophysical Research Communications·Ilya G VyatchinNikolay S Shelud'ko
May 1, 2001·Biochemistry·D FunabaraD J Hartshorne
Dec 7, 2007·The Journal of Experimental Biology·Daisuke FunabaraShugo Watabe
Feb 2, 2006·The Journal of Experimental Biology·Marion Christine HöpflingerStefan Galler
Sep 12, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·N Shelud'koO Matusovsky
Nov 16, 2004·Archives of Biochemistry and Biophysics·Nikolai S Shelud'koOleg S Matusovsky
Feb 14, 2006·Biophysical Journal·Thomas M ButlerMarion J Siegman
Apr 22, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·N OdintsovaN Shelud'ko
Sep 15, 2006·Archives of Biochemistry and Biophysics·Apolinary SobieszekNikolay S Shelud'ko
May 1, 2007·Biophysical Journal·Aaron S FrankeThomas M Butler
Jan 12, 2010·Archives of Biochemistry and Biophysics·Yurii S BorovikovStanislava V Avrova

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