PMID: 15328769Aug 27, 2004Paper

Phosphorylation of extracellular signal-regulated protein kinase in cultured keloid fibroblasts when stimulated by platelet-derived growth factor BB

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
Chuan Jun LiuSanyang Gao

Abstract

Abnormal scars result in distressing symptoms and disfiguring blemishes; an understanding of the molecular events that cause such scars, particularly keloids, would make possible the optimisation of both wound healing and treatment. Extracellular signal-regulated protein kinase (ERK) has a crucial role in distinct signalling pathways in different cells, but to date we know of no study on its signalling events in keloid fibroblasts. The purpose of this study was to characterise the expression of tyrosine phosphorylation kinases, particularly that of ERK, in keloids at the protein level by immunoblotting analysis. Studies on phosphorylation were made on cell lysates of three cultures of five different keloid fibroblasts (n = 5), their relatively 'normal' fibroblasts in adjacent skin (rNHDF, n = 5), and normal human dermal fibroblasts (n = 1, standard control). The result showed that ERK signalling molecular protein was more highly phosphorylated in keloid fibroblast culture than in the other two cultures.

References

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Citations

Jun 9, 2012·International Journal of Nanomedicine·Yong-Tai ZhangNian-Ping Feng
Oct 2, 2009·Clinics in Plastic Surgery·Adil Ladak, Edward E Tredget
Sep 17, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Naqi Lian, Taiping Li
Sep 10, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alexis ArmourEdward E Tredget
Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shikun ZhangLing Leng

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