Phosphorylation of GSK-3β and reduction of apoptosis as targets of troxerutin effect on reperfusion injury of diabetic myocardium

European Journal of Pharmacology
Behnaz MokhtariMustafa Mohammadi

Abstract

Diabetes has various interactions with ischemic heart diseases. Troxerutin, a flavonoid, owns outstanding pharmacological potentials in cardiovascular medicine. The purpose of this study was to investigate the effects of troxerutin on phosphorylation of GSK-3β protein and apoptosis induced by myocardial ischemia-reperfusion injury in healthy and diabetic hearts. Male Wistar rats (n=36, 250-300 g) were randomly divided into four groups: healthy, diabetic, healthy-troxerutin and diabetic-troxerutin. Diabetes was induced by a single injection of streptozotocin (50 mg/kg; ip) and the diabetic period was lasted for ten weeks. Six weeks after induction of diabetes, troxerutin-treated groups received 150 mg/kg/day troxerutin by oral gavage for 4 weeks. The rats' hearts were transferred to the Langendorff apparatus and then subjected to 30 min regional ischemia followed by 45 min reperfusion. Supernatants of the left ventricle were used to measure the levels of cardiac troponin-I (cTnI) by ELISA, total and phosphorylated form of GSK-3β by western blotting and tissue apoptosis by TUNEL assay. Troxerutin administration significantly decreased the cTnI levels in healthy and diabetic groups, as compared to the corresponding controls (P<0.0...Continue Reading

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Citations

Mar 13, 2017·European Journal of Pharmacology·Tourandokht BaluchnejadmojaradMehrdad Roghani
Sep 14, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Goltaj BayramiReza Badalzadeh
Feb 15, 2018·European Journal of Preventive Cardiology·Feyzizadeh SaeidVafaee S Manouchehr
Oct 28, 2019·Human Molecular Genetics·Sara J HolditchCharles L Edelstein
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Qun ShanYuan-Lin Zheng
Jul 1, 2020·Endocrine Regulations·Afsaneh GhadiriRana Keyhanmanesh
Apr 10, 2021·Journal of Pharmacopuncture·Zahra AhmadiMilad Ashrafizadeh
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Moslem NajafiReza Badalzadeh

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