Abstract
Diabetes has various interactions with ischemic heart diseases. Troxerutin, a flavonoid, owns outstanding pharmacological potentials in cardiovascular medicine. The purpose of this study was to investigate the effects of troxerutin on phosphorylation of GSK-3β protein and apoptosis induced by myocardial ischemia-reperfusion injury in healthy and diabetic hearts. Male Wistar rats (n=36, 250-300 g) were randomly divided into four groups: healthy, diabetic, healthy-troxerutin and diabetic-troxerutin. Diabetes was induced by a single injection of streptozotocin (50 mg/kg; ip) and the diabetic period was lasted for ten weeks. Six weeks after induction of diabetes, troxerutin-treated groups received 150 mg/kg/day troxerutin by oral gavage for 4 weeks. The rats' hearts were transferred to the Langendorff apparatus and then subjected to 30 min regional ischemia followed by 45 min reperfusion. Supernatants of the left ventricle were used to measure the levels of cardiac troponin-I (cTnI) by ELISA, total and phosphorylated form of GSK-3β by western blotting and tissue apoptosis by TUNEL assay. Troxerutin administration significantly decreased the cTnI levels in healthy and diabetic groups, as compared to the corresponding controls (P<0.0...Continue Reading
References
Jan 1, 1989·Atherosclerosis·A J OlszewskiK S McCully
May 29, 2002·Diabetes·Lu CaiY James Kang
Feb 14, 2004·Cardiovascular Research·Andrew P HalestrapSabzali A Javadov
Feb 14, 2004·Cardiovascular Research·Derek J Hausenloy, Derek M Yellon
Feb 8, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·B S AdamM Tegtmeier
May 30, 2006·Biochimica Et Biophysica Acta·Nathan R BradyRoberta A Gottlieb
Feb 8, 2008·Clinical Cardiology·Mouaz Al-MallahHenry E Kim
Feb 13, 2008·Cardiovascular Research·Tuanzhu HaChuanfu Li
Nov 13, 2008·International Immunopharmacology·Shao-Hua FanYan-Yan Wang
Sep 3, 2009·Journal of Agricultural and Food Chemistry·Zi-feng ZhangBin Hu
Sep 22, 2009·Neurobiology of Learning and Memory·Jun LuYong-Jian Wang
Jan 22, 2011·Brain : a Journal of Neurology·Jun LuZi-feng Zhang
Aug 9, 2011·Experimental Diabetes Research·Xia YinLu Cai
Aug 11, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Reza BadalzadehHadi Ebrahimi
Nov 2, 2011·Current Cardiology Reviews·Kenichi WatanabeYoshifusa Aizawa
Mar 29, 2012·Heart Failure Reviews·Takayuki MikiTetsuji Miura
Jun 15, 2012·Cardiovascular Diabetology·Takayuki MikiTetsuji Miura
May 28, 2014·Journal of Hepatology·Hailong FuXueyin Shi
Jul 16, 2014·Biochemical Pharmacology·Zi-Feng ZhangBin Hu
Dec 2, 2014·Journal of Diabetes and Metabolic Disorders·Moslem NajafiMohammad Amani
Mar 3, 2015·The Journal of Physiological Sciences : JPS·Reza BadalzadehRaana Yavari
May 1, 2015·International Journal of Endocrinology and Metabolism·Reza BadalzadehMustafa Mohammadi
Oct 28, 2015·Advanced Pharmaceutical Bulletin·Reza BadalzadehShima Mohammadi
Citations
Aug 5, 2016·Journal of Cardiovascular and Thoracic Research·Nasser SafaeiReza Badalzadeh
Mar 13, 2017·European Journal of Pharmacology·Tourandokht BaluchnejadmojaradMehrdad Roghani
Sep 14, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Goltaj BayramiReza Badalzadeh
Feb 15, 2018·European Journal of Preventive Cardiology·Feyzizadeh SaeidVafaee S Manouchehr
Sep 19, 2019·Acta Cirúrgica Brasileira·Dajun WeiYing Jiang
Mar 13, 2020·Journal of Cellular and Molecular Medicine·Yan-Rong ZhuDai-Min Zhang
Mar 4, 2020·The International Journal of Neuroscience·Hóngyi ZhàoYonghua Huang
Mar 20, 2016·Journal of Pineal Research·Hong-Hwa ChenHon-Kan Yip
Oct 28, 2019·Human Molecular Genetics·Sara J HolditchCharles L Edelstein
Feb 21, 2018·Andrologia·A HazratiA Alihemmati
Aug 3, 2017·Molecular Medicine Reports·Yong LiJianguo Ji
Nov 8, 2018·Journal of Diabetes Research·Xiangyang ChengZhenghong Li
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Hóngyi ZhàoYonghua Huang
Nov 4, 2016·Inflammation·Reza BadalzadehAzam Abbaszadeh
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Qun ShanYuan-Lin Zheng
Dec 7, 2018·Scientific Reports·Cheng ZengJianguo Xing
Sep 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jianbo GuoQingyong He
Jul 20, 2018·Advanced Pharmaceutical Bulletin·Goltaj BayramiReza Badalzadeh
Jul 1, 2020·Endocrine Regulations·Afsaneh GhadiriRana Keyhanmanesh
Apr 10, 2021·Journal of Pharmacopuncture·Zahra AhmadiMilad Ashrafizadeh
Apr 28, 2021·Free Radical Biology & Medicine·Monika BartekováZoltán Giricz
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Moslem NajafiReza Badalzadeh
May 11, 2020·Current Neuropharmacology·Mohammad ZamanianSamira Shirooie