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Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity

The Journal of Investigative Dermatology

Mar 4, 2011

Tatsushi ToyookaYuko Ibuki

Abstract

Several light-absorbing chemicals are known to show phototoxic effects involving many kinds of DNA damage, and are suspected of initiating skin cancer. In this study, we clarified that phosphorylated histone H2AX (γ-H2AX) (phosphorylated histone H2AX), which was produced with the induct...read more

Mentioned in this Paper

Malignant Neoplasm of Skin
H2AFX gene
H2AFX wt Allele
Keratinocyte
Mutagenicity Tests
Protein Phosphorylation
H2AX protein, human
Coumarins
Phototoxicity
Skin Neoplasms
1
29
Paper Details
References
  • References34
  • Citations17
1234
  • References34
  • Citations17
12

Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity

The Journal of Investigative Dermatology

Mar 4, 2011

Tatsushi ToyookaYuko Ibuki

PMID: 21368771

DOI: 10.1038/jid.2011.28

Abstract

Several light-absorbing chemicals are known to show phototoxic effects involving many kinds of DNA damage, and are suspected of initiating skin cancer. In this study, we clarified that phosphorylated histone H2AX (γ-H2AX) (phosphorylated histone H2AX), which was produced with the induct...read more

Mentioned in this Paper

Malignant Neoplasm of Skin
H2AFX gene
H2AFX wt Allele
Keratinocyte
Mutagenicity Tests
Protein Phosphorylation
H2AX protein, human
Coumarins
Phototoxicity
Skin Neoplasms
1
29

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Paper Details
References
  • References34
  • Citations17
1234
  • References34
  • Citations17
12
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