PMID: 6976966Dec 1, 1981Paper

Phosphorylation of myosin light chain during capping of mouse T-lymphoma cells

The Journal of Cell Biology
L Y BourguignonY C Hsing

Abstract

Colchicine induces the clustering of at least three different T-lymphoma surface antigens (T200, Thy-1, and gp 69/71) into a cap structure in the absence of any external ligand. In addition, colchicine induces the intracellular accumulation of actin and myosin directly beneath the surface cap structure. We have discovered that myosin molecules (both heavy and light chains) are closely associated with the plasma membrane of T-lymphoma cells. Most importantly, we have found that the 20,000-dalton light chain of lymphocyte myosin is both phosphorylated and preferentially accumulated in the plasma membrane of colchicine-induced capped cells. It is proposed that myosin light chain is directly involved in the activation of membrane-associated actomyosin required for the collection of surface proteins into a cap structure (analogous to muscle cell sliding filament contraction).

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Citations

Jan 1, 1983·The Journal of Membrane Biology·L Y Bourguignon, B C Pressman
Jan 1, 1988·The International Journal of Biochemistry·J Kuznicki, B Baryłko
Jan 1, 1990·International Journal of Immunopharmacology·A SatoS Shigeta
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Aug 26, 2011·The Journal of Biological Chemistry·Beiyi ShenStephen J Gould
Mar 1, 1985·The Journal of Cell Biology·C Pasternak, E L Elson
Aug 1, 1985·The Journal of Cell Biology·L Y BourguignonJ R Glenney
Dec 1, 1986·The Journal of Cell Biology·L Y BourguignonE L Kalomiris
Dec 1, 1982·The Journal of Cell Biology·L Y BourguignonA R Means
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May 16, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Masaaki HigashiharaKouji Miyazaki
Oct 7, 2006·Biochemical and Biophysical Research Communications·Kenji MiyauchiHiroshi Hosoya
Jan 1, 1988·Journal of Cellular Physiology·S J SuchardL Y Bourguignon
Sep 1, 1985·Journal of Cellular Physiology·M H Majercik, L Y Bourguignon
Jan 9, 1987·Biochimica Et Biophysica Acta·S J Suchard, L Y Bourguignon
Jul 5, 2001·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·M WatanabeM Higashihara
Feb 1, 1983·Biochimica Et Biophysica Acta·L Y Bourguignon, Y C Hsing

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