Phosphorylation of neurofilament proteins and localization of axonal swellings in motor neuron disease

Journal of the Neurological Sciences
I ToyoshimaM Satake

Abstract

Seven lumbosacral spinal cords with motor neuron disease were examined immunocytochemically with monoclonal antibodies (MAb) directed against neurofilament proteins (NFP). Each of the 5 MAbs used in this study was monospecific to one of the triplet of NFP. Two of them were specific to the highly phosphorylated form of high molecular weight peptide of NFP (NFP-H). All 5 MAbs stained all axonal swellings examined. In 2 spinal cords examined, some axonal swellings were found in the anterolateral funiculus and some of these were as far as 1000 microns from the grey matter. This localization of axonal swellings suggests that a high degree of phosphorylation of NFP is not the cause of accumulation of NFP in axonal swellings in motor neuron disease.

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Citations

Feb 3, 2009·Molecular Neurobiology·Kohsuke KanekuraMasaaki Matsuoka
Aug 13, 1998·Journal of the Neurological Sciences·I ToyoshimaO Masamune
Apr 1, 1991·Journal of Neurochemistry·C Pekiner, W G McLean
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Brian T HelfandRobert D Goldman
Jan 27, 2007·The American Journal of Pathology·Erin H NorrisVirginia M-Y Lee
Jun 4, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D M F MendonçaA M B Martinez
Jun 7, 2005·Muscle & Nerve·Michio KobayashiItaru Toyoshima

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