PMID: 5919445Nov 11, 1966

Phosphorylation of nuclear protein early in the course of gene activation in lymphocytes

L J KleinsmithA E Mirsky


Human lymphocytes treated with phytohemagglutinin undergo extensive gene activation, as evidenced by augmented synthesis of ribonucleic acids. This activation is preceded by an early stimulation in the rate of phosphorylation and dephosphorylation of nuclear proteins. This finding is consistent with a hypothesized role of phosphoproteins in the modification of chromatin structure and in modulation of the template activity of DNA in vivo.


Jan 1, 1987·Cancer Metastasis Reviews·J F WhitfieldP R Walker
Jan 1, 1983·Molecular and Cellular Biochemistry·D B Jump, J H Oppenheimer
Sep 1, 1975·Biulleten' eksperimental'noĭ biologii i meditsiny·S N BykovskaiaA M Shepelenko
Nov 9, 1979·Biochimica Et Biophysica Acta·W ThornburgT J Lindell
Jul 22, 1969·Biochimica Et Biophysica Acta·J E Kay, H L Cooper
Dec 21, 1978·Biochimica Et Biophysica Acta·D I Stott, A R Williamson
Jul 1, 1968·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J G GeorgatsosA Symeonidis
Jan 1, 1974·Advances in Enzyme Regulation·A G Gornall, C C Liew
Jul 1, 1983·Archives of Gerontology and Geriatrics·M K Thakur
Jan 1, 1976·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R D Platz, L J Kleinsmith
Jan 1, 1978·General Pharmacology·S Itzhaki, M J Capps
Jan 24, 1974·The New England Journal of Medicine·R Levy, H S Kaplan
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D B Fisher, G C Mueller
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·C C Liew, C C Yip
Jul 1, 1968·The Journal of Experimental Medicine·G B OlsonR A Good
Jan 31, 1973·The Journal of Experimental Medicine·R R Rich, C W Pierce
Oct 1, 1970·British Journal of Haematology·K C Das, A V Hoffbrand
Nov 7, 1972·European Journal of Biochemistry·I Betel, K J van den Berg
May 17, 1976·European Journal of Biochemistry·W SonsR Knippers
Jan 1, 1972·Transplantation Reviews·H L Cooper
Jun 1, 1981·Environmental Health Perspectives·J B Silkworth, L D Loose
Jan 9, 2014·Cancer Metastasis Reviews·Deanna Dryhurst, Juan Ausió
Dec 15, 1969·Klinische Wochenschrift·G Brittinger, E König
Dec 23, 1969·Biochimica Et Biophysica Acta·E L Gershey, L J Kleinsmith
Nov 11, 1969·Biochimica Et Biophysica Acta·E L Gershey, L J Kleinsmith
Jun 13, 1975·Annals of the New York Academy of Sciences·J W Hadden
Dec 13, 1976·Biochimica Et Biophysica Acta·M L Goldberg, C G Biava
Oct 14, 1971·Biochimica Et Biophysica Acta·J E KayM Atkins
Mar 8, 1974·Biochimica Et Biophysica Acta·J Blankenship, E Bresnick
Sep 1, 1976·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·W C Dewey, R B Brannon
Dec 23, 1970·FEBS Letters·R D PlatzL J Kleinsmith
Apr 2, 1979·European Journal of Biochemistry·C Guguen-GuillouzoJ Kruh
Apr 3, 1968·European Journal of Biochemistry·J E Kay
Jun 1, 1974·European Journal of Biochemistry·F Lamy, J E Dumont
Jan 1, 1974·Beiträge Zur Pathologie·R Baserga
Jun 1, 1973·Experimental Cell Research·C H de Bruyn, T L Oei
Jun 1, 1973·Experimental Cell Research·E M LeStourgeonH P Rusch
Feb 1, 1968·Experimental Cell Research·G R Shepherd, B J Noland
Aug 1, 1968·Experimental Cell Research·J F Whitfield, A D Perris
Jul 14, 1978·Biochemical and Biophysical Research Communications·F Farron-Furstenthal, J R Lightholder
Nov 3, 1975·Biochemical and Biophysical Research Communications·F Farron-Furstenthal
Nov 1, 1967·Experimental Cell Research·J F WhitfieldA D Perris
Feb 1, 1972·Journal of Ultrastructure Research·L RecherL Briggs
Mar 1, 1975·Experimental Cell Research·J F ChiuL S Hnilica
Nov 9, 1970·Biochemical and Biophysical Research Communications·C T TengV G Allfrey
Nov 1, 1969·Experimental Cell Research·J E Kay
Jan 1, 1969·Experimental Cell Research·B B Mukherjee, S K Ghosal
Nov 1, 1972·Experimental Cell Research·G Auer, A Zetterberg
Jan 1, 1970·Experimental Cell Research·I BetelM A Graver
Mar 15, 1978·Experimental Cell Research·M DerenziniA Pession-Brizzi
Oct 1, 1968·Experimental Cell Research·J F WhitfieldT Youdale
Sep 1, 1972·Cellular Immunology·R B Whitney, R M Sutherland
Apr 1, 1970·Experimental Cell Research·J P Monjardino, A J MacGillivray
Apr 2, 1973·Biochemical and Biophysical Research Communications·R D PlatzL J Kleinsmith
Jan 23, 1973·Biochemical and Biophysical Research Communications·M Shea, L J Kleinsmith
Nov 1, 1972·Archives of Biochemistry and Biophysics·K R SheltonJ M Neelin
Aug 1, 1971·Experimental Cell Research·G R ShepherdJ M Hardin
Feb 25, 1972·Biochemical and Biophysical Research Communications·R W Ruddon, S L Anderson
Feb 15, 2012·Brain Research·Olena BabenkoGerlinde A Metz
May 15, 1984·Archives of Biochemistry and Biophysics·S Offenbacher, E S Kline
Jan 1, 1983·Journal of Cellular Biochemistry·R C BriggsL S Hnilica
Sep 2, 1975·Biochemical and Biophysical Research Communications·S Offenbacher, E S Kline
Jun 18, 1974·Biochemical and Biophysical Research Communications·O J Martelo, J Hirsch
Oct 27, 1975·Biochemical and Biophysical Research Communications·L D Johnson, J W Hadden
Oct 1, 1975·Archives of Biochemistry and Biophysics·C S Cobbs, K R Shelton
Sep 5, 1973·Biochemical and Biophysical Research Communications·R D Platz, L S Hnilica
Sep 5, 1973·Biochemical and Biophysical Research Communications·L E Rikans, R W Ruddon
Oct 1, 1972·Archives of Biochemistry and Biophysics·E M Johnson, V G Allfrey
Jun 15, 2015·Progress in Neurobiology·Roy LardenoijeBart P F Rutten
Aug 2, 1979·Nature·F Farron-Furstenthal
Jul 1, 1975·Journal of Dairy Science·K S McCarty, K S McCarty
Jun 1, 1982·European Journal of Biochemistry·T B Sculley, A G Mackinlay
Oct 1, 1977·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S R Umansky, A D Domashenko
May 1, 1972·Die Naturwissenschaften·P Chandra, D Gericke

Related Concepts

Lymphoid Cells
Animal Lectins

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
L J KleinsmithA E Mirsky
Biochimica Et Biophysica Acta
E L Gershey, L J Kleinsmith
© 2021 Meta ULC. All rights reserved