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Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependent kinase

The Journal of Biological Chemistry

Nov 18, 2010

Hyeon-Son ChoiGeorge M Carman

Abstract

The Saccharomyces cerevisiae PAH1-encoded phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol and plays a role in the transcriptional regulation of phospholipid synthesis genes. PAP is phosphorylated at multiple Ser and Thr residues and is ...read more

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
ISYNA1 gene
Cyclin-Dependent Kinases
Phosphoric Monoester Hydrolases
Saccharomyces cerevisiae allergenic extract
Membrane Fraction
Mutagenesis, Site-Directed
SMP2 protein, S cerevisiae
Protein Phosphorylation
CDK1 gene
Paper Details
References
  • References52
  • Citations48
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  • References52
  • Citations48
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Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-dependent kinase

The Journal of Biological Chemistry

Nov 18, 2010

Hyeon-Son ChoiGeorge M Carman

PMID: 21081492

DOI: 10.1074/jbc.m110.155598

Abstract

The Saccharomyces cerevisiae PAH1-encoded phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol and plays a role in the transcriptional regulation of phospholipid synthesis genes. PAP is phosphorylated at multiple Ser and Thr residues and is ...read more

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
ISYNA1 gene
Cyclin-Dependent Kinases
Phosphoric Monoester Hydrolases
Saccharomyces cerevisiae allergenic extract
Membrane Fraction
Mutagenesis, Site-Directed
SMP2 protein, S cerevisiae
Protein Phosphorylation
CDK1 gene

Feeds With Similar Papers

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

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Phosphatidate phosphatase, a key regulator of lipid homeostasis

Biochimica Et Biophysica ActaAugust 23, 2012
Florencia Pascual, George M Carman
Paper Details
References
  • References52
  • Citations48
12345...
  • References52
  • Citations48
12345

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