Phosphorylation of phospholipase C-coupled receptors

Pharmacology & Therapeutics
A B Tobin

Abstract

Early work on G-protein-coupled receptor (GPCR) phosphorylation focused on the adenylyl cyclase-linked beta-adrenoceptor, where phosphorylation at sites on the C-terminal tail and within the third intracellular loop results in receptor desensitisation. In recent years, intense research activity has revealed that a large number of GPCR subtypes exist as phosphoproteins, where the level of phosphorylation is dramatically increased subsequent to receptor stimulation. Among these receptor subtypes are those receptors coupled to phospholipase C (PLC). It appears, therefore, that regulation via receptor phosphorylation is a mechanism employed by all but a few GPCRs, including those coupled to PLC. Because the majority of GPCRs are coupled to the phosphoinositide signalling pathway, receptor phosphorylation of PLC-coupled receptors is a regulatory process with profound physiological significance for a huge array of biological responses. This review discusses the properties of homologous and heterologous phosphorylation of PLC-coupled receptors, together with the receptor kinases involved and the functional significance of receptor phosphorylation.

References

Mar 16, 1992·Biochemical and Biophysical Research Communications·J S Anant, B K Fung
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N S RothM J Lohse
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W LorenzR J Lefkowitz
Oct 1, 1991·Trends in Biochemical Sciences·K Palczewski, J L Benovic
Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C C FelderJ Wess
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S M MumbyP C Sternweis
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R B ClarkJ A Johnson
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R H StrasserR J Lefkowitz
Jan 1, 1986·Current Topics in Cellular Regulation·R J Lefkowitz, M G Caron
Jan 1, 1987·Annual Review of Biochemistry·M J Berridge
Jun 15, 1984·The Biochemical Journal·P Thompson, J B Findlay
Jan 1, 1995·Vitamins and Hormones·R Sterne-Marr, J L Benovic
Feb 17, 1995·The Journal of Biological Chemistry·F Ozcelebi, L J Miller
Aug 4, 1995·The Journal of Biological Chemistry·T T ChuangA De Blasi
Aug 11, 1995·The Journal of Biological Chemistry·E GianniniF Boulay
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P Kunapuli, J L Benovic
Nov 7, 1993·Biochimica Et Biophysica Acta·M J Lohse
Feb 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R T PremontR J Lefkowitz
Jun 16, 1995·The Journal of Biological Chemistry·H OhguroK Palczewski
Mar 17, 1995·The Journal of Biological Chemistry·S K DebBurmanM M Hosey
Sep 1, 1994·Trends in Biochemical Sciences·T J GibsonE Birney
Apr 1, 1994·Trends in Pharmacological Sciences·R M EglenR A Challiss
Aug 1, 1994·Journal of Neurochemistry·T HagaK Kameyama
Apr 1, 1994·The American Journal of Physiology·Z ZhuL J Miller
Jul 1, 1993·Trends in Pharmacological Sciences·R J WojcikiewiczS R Nahorski
Sep 1, 1993·Trends in Biochemical Sciences·A MusacchioM Saraste
Jan 28, 1993·Nature·M J Berridge
Aug 13, 1993·Cell·R J Lefkowitz

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Citations

Mar 26, 2003·Life Sciences·Dirk Van OekelenJosée E Leysen
Sep 28, 1998·Pharmacology & Therapeutics·E Hermans, J M Maloteaux
Jan 23, 2003·Reproductive Biomedicine Online·O OrtmannK Diedrich
Apr 26, 2000·British Journal of Pharmacology·R M Eglen, S R Nahorski
Nov 13, 2001·British Journal of Pharmacology·P N BernatchezM G Sirois
Feb 5, 1999·The Biochemical Journal·M G WaughA B Tobin
Jun 3, 2004·The Journal of General Physiology·Byung-Chang SuhBertil Hille
Apr 29, 2011·American Journal of Physiology. Cell Physiology·Jie HongWeibiao Cao
Nov 15, 2006·Autoimmunity·Hjalmar Kurzen, Sarah Brenner
Apr 16, 2008·European Journal of Pharmacology·Mariëlle C Hendriks-BalkAstrid E Alewijnse
Feb 8, 2005·The Journal of Biological Chemistry·Serge HardyMarc Prentki
Nov 24, 1999·The Journal of Biological Chemistry·C V CarmanT Kozasa
Apr 25, 2000·The Journal of Biological Chemistry·D C BuddA B Tobin
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·A González IglesiasD Becu-Villalobos
Mar 22, 2003·The Journal of Biological Chemistry·David C BuddAndrew B Tobin
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa A ByersCharlotte M Vines
Nov 24, 1999·The American Journal of Physiology·G B WillarsS R Nahorski
Aug 8, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Juergen M WeissOlaf Ortmann

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